To investigate the effects of Jianpi Qushi Decoction on lipid metabolism in obese patients with diabetes mellitus. Methods:A total of 100 cases of obese patients with diabetes mellitus admitted in Nanyang First People's Hospital from January 2016 to January 2017 were selected and randomly divided into control group and observation group, with 50 cases in each group. The control group was treated with atorvastatin while observation group was treated with Jianpi Qushi Decoction on the basis of the same treatment. The total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), body weight, and body mass index（BMI）, waist circumference were measured before and after12 weeks treatment. The clinical efficacy and incidence of adverse reactions was compared. Results:After the treatment, the levels of TC, TG, LDL-C, body weight and BMI were significantly decreased in both groups (P<0.05), and HDL-C level was significantly increased (P<0.05). There was a significant difference between the two groups (P<0.05). The total effective rate in observation group (92%) was significantly higher than that in control group (76%) (P<0.05). The incidence of adverse reactions in observation group (4%) was significantly lower than that in control group (16%) (P<0.05). Conclusion:The Jianpi Qushi Decoction can improve the lipid metabolism of obese patients with type 2 diabetes mellitus, and control the weight of patients significantly. The clinical efficacy is remarkable, which is worthy of clinical reference and promotion.