To explore the clinical efficacy of Weifuchun Pill on Helicobacter pylori (H.pylori) positive chronic atrophic gastritis and effects on pH and pepsinogen in gastric juice.Methods:A total of 200 patients with H.pylori positive chronic atrophic gastritis treated in the Department of Geriatrics and the Department of Spleen and Stomach Diseases of Affiliated Hospital of Integrated Traditional Chinese and Western Medicine of Nanjing University of Chinese Medicine from August 2014 to August 2016 were selected and randomly divided into control group and study group,with 100 cases in each group.In both groups,the basic anti-Helicobacter pylori treatment was performed by standard triple therapy,and the observation group was given Weifuchun tablets on the basis of this treatment for 4 weeks.After treatment,the gastric juice pH,Helicobacter pylori positive rate,pepsinogen and curative efficacy were compared between 2 groups.Results:Compared with before treatment,the level of pH in stomach of both groups was increased significantly after the treatment,and the study group increased more than the control group (P<0.01).Compared with before treatment,the positive rate of Helicobacter pylori in both groups was decreased significantly,and the study group decreased more than the control group (P<0.01).The levels of pepsin 1 and 2 in the 2 groups were significantly increased,and the study group increased more than that of the control group (P<0.01).After treatment,the total effective rate of the study group was 93.83%,which was significantly higher than that of the control group (79.07%) (P<0.01).Conclusion:Weifuchun Pills has significant clinical effects on Helicobacter pylori positive chronic atrophic gastritis,and can improve gastric juice pH and pepsinogen levels.