To study the effects of Shenfu Injection on cardiac function and myocardial fibrosis in patients with ischemic cardiomyopathy and acute heart failure.Methods:A total of 68 patients with ischemic cardiomyopathy and acute heart failure treated in Yankuang Group General Hospital from February 2015 to November 2017 were selected and divided into control group and observation group according to the random table method,with 34 cases in each group.Both groups were given conventional medicine,the observation group was additionally given Shenfu Injection on the basis of this treatment for 2 weeks.The clinical efficacy of both groups was evaluated after treatment.The changes of cardiac function indexes and the levels of myocardial fibrosis indexes in both groups were observed and compared before and after treatment.Results:The total effective rate of observation group was 94.12%,which was significantly higher than 76.47% of control group (P<0.05).The LVEDD,LVESD,LVEDV and LVESV of both groups significantly decreased after treatment,and observation group decreased more significantly than control group (P<0.05 or P<0.01).The LVEF of both groups significantly increased,and observation group increased more significantly than the control group (P<0.01).After treatment,the levels of myocardial fibrosis indexes such as PCⅠ,PCⅢ,HA,LN and Gal-3 in both groups significantly decreased,and observation group decreased more significantly than control group (P<0.05 or P<0.01).Conclusion:Shenfu Injection can significantly improve cardiac function of patients with ischemic cardiomyopathy and acute heart failure,reduce the degree of myocardial fibrosis,and improve the overall clinical efficacy.