To study the clinical effect of Yiqi Qingre Jiedu Huayu Method in the treatment of ulcerative colitis and effects on the high coagulation state and inflammatory factors.Methods:A total of 130 patients with ulcerative colitis treated in Baoji Maternal and Child Health Hospital from June 2015 to August 2017 were selected and randomly divided into control group and observation group,with 65 cases in each group.The control group was given conventional treatment,while the observation group was treated with Yiqi Qingre Jiedu Huayu Method based on the same treatment of control group.Both groups were treated for 2 months to observe the clinical efficiency and adverse reactions and to compare the indexes of high coagulation state,inflammatory factors,clinical symptom scores before and after treatment.Results:The total effective rate of observation group was 93.85% (61/65),which was higher than the 80.00% (52/65) of the control group (P<0.05).No serious adverse reactions occurred during the treatment of both groups.After 2 months' treatment,the tumor necrosis factor-α (TNF-α),interleukin-6 (IL-6),high sensitive C reactive protein (hs-CRP),Platelet (Plt),D-two polymer,fibrinogen (FIB) of both groups were significantly reduced,and the observation group were lower than that in the control group (P<0.05).After 2 months' treatment,the clinical symptom scores and colonoscopy integral of both groups were significantly reduced,and the scores of observation group reduced more than that in the control group (P<0.05).Conclusion:Yiqi Qingre Jiedu Huayu Method in the treatment of ulcerative colitis has significant effects,which can effectively improve hypercoagulability,reduce the level of inflammatory factors,improve the symptom scores,and it is safe and worthy of further promotion.