To study the effects of Rhodiola sachalinensis on unstable angina pectoris (UAP) patients and its effects on myocardial injury and platelet activity.Methods:A total of 88 cases of UAP patients in our hospital during February 2015 to January 2017 were chosen as research subject.All patients were randomly divided into control group and observation group according to the random number table method, with 44 cases in each group.Patients in control group were treated with routine western medicine treatment, and those in observation group were treated with western medicine combined with Rhodiola sachalinensis treatment.Both treatments lasted for 8 weeks.The short-term effects of two groups were compared.Serum markers of myocardial injury and platelet activity indexes in peripheral blood were observed.Results:8 weeks after treatment, total effective rate in observation group was higher than that in control group (P<0.05); serum myocardial injury markers such as BNP, cTn, CK-MB were lower than those in control group (P<0.05); platelet activity indexes such as CD42b in observation group in peripheral blood was higher than that in control group, and CD63, PAC-1 levels were lower than those in control group (P<0.05).Conclusion:Treatment of Rhodiola sachalinensis on unstable angina pectoris patients can effectively improve the short-term efficacy, and the specific mechanism is directly related to the protection of myocardial cells and inhibition of platelet activity.