| 引用本文:吕静静，葛阳涛，马燕楠.大株红景天治疗不稳定型心绞痛的疗效及对心肌损伤、血小板活性的影响[J].世界中医药,2018,(09):. |
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| 大株红景天治疗不稳定型心绞痛的疗效及对心肌损伤、血小板活性的影响 |
| Curative Effects of Rhodiola Sachalinensis on Unstable Angina Pectoris Patients and Its Effects on Myocardial Injury and Platelet Activity |
| 投稿时间：2017-09-23 |
| DOI：10.3969/j.issn.1673-7202.2018.09.024 |
| 中文关键词: 不稳定型心绞痛 大株红景天 阿托伐他汀 疗效 心肌损伤 B型尿钠肽 心肌肌钙蛋白 血小板活性 |
| English Keywords:Unstable angina pectoris Rhodiola sachalinensis Atorvastatin Effect Myocardial damage B type natriuretic peptide Cardiac troponin Platelet activity |
| 基金项目:2015年度河南省医学科技攻关计划项目(201504048) |
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| 中文摘要: |
| 目的：探讨大株红景天治疗不稳定型心绞痛的疗效及对心肌损伤、血小板活性的影响。方法：选取2015年2月至2017年1月郑州市中医院收治的不稳定型心绞痛患者88例，按照随机数表法分为对照组和观察组，每组44例。对照组接受常规西医治疗，观察组接受西医联合大株红景天治疗，均持续8周。分析2组患者的近期疗效，血液中心肌损伤、血小板活性指标。结果：治疗8周后，观察组治疗总有效率高于对照组（P<0.05）；观察组血清B型尿钠肽（BNP）、心肌肌钙蛋白（cTn）、肌酸激酶同工酶（CK-MB）的水平低于对照组（P<0.05）；观察组CD42b的水平高于对照组，CD63、PAC-1的水平低于对照组（P<0.05）。结论：不稳定型心绞痛患者接受大株红景天辅助治疗，可有效提升近期疗效，具体作用机制与其保护心肌细胞、抑制血小板活性直接相关。 |
| English Summary: |
| To study the effects of Rhodiola sachalinensis on unstable angina pectoris (UAP) patients and its effects on myocardial injury and platelet activity.Methods:A total of 88 cases of UAP patients in our hospital during February 2015 to January 2017 were chosen as research subject.All patients were randomly divided into control group and observation group according to the random number table method, with 44 cases in each group.Patients in control group were treated with routine western medicine treatment, and those in observation group were treated with western medicine combined with Rhodiola sachalinensis treatment.Both treatments lasted for 8 weeks.The short-term effects of two groups were compared.Serum markers of myocardial injury and platelet activity indexes in peripheral blood were observed.Results:8 weeks after treatment, total effective rate in observation group was higher than that in control group (P<0.05); serum myocardial injury markers such as BNP, cTn, CK-MB were lower than those in control group (P<0.05); platelet activity indexes such as CD42b in observation group in peripheral blood was higher than that in control group, and CD63, PAC-1 levels were lower than those in control group (P<0.05).Conclusion:Treatment of Rhodiola sachalinensis on unstable angina pectoris patients can effectively improve the short-term efficacy, and the specific mechanism is directly related to the protection of myocardial cells and inhibition of platelet activity. |
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