To investigate the clinical efficacy of Modified Bazhen Decoction with adjuvant therapy of chemotherapy on advanced non-small cell lung cancer and its toxic and side effects on chemotherapy.Methods:A total of 154 patients with advanced non-small cell lung cancer treated in Department of Internal Medicine in Navy General Hospital from September 2014 to December 2016 were selected and divided into control group and observation group according to random number table method,with 77 patients in each group.The control group was treated with GP chemotherapy regimen,and the patients in the experiment group were given Modified Bazhen Decoction on the basis of the same treatment of control group.The level of blood cells,the levels of T lymphocyte in peripheral blood,the quality of life score in both group after the treatment were observed and recorded,and the clinical effect and the incidences of adverse reaction were compared.Results:The effective rate of the experiment group (51.95%) was significantly higher than that of the control group (35.07%) (P<0.05).After treatment,compared with the control group,the serum levels of red blood cell (RBC),white blood cell (WBC) and platelet (PLT) increased in the observation group,the peripheral blood CD3+、CD4+ T lymphocytes and CD4+/ CD8+ levels were increased,and the contents of the FACT-L scale score and the total score were increased (P<0.05).The adverse reactions of patients in both groups mainly consist gastrointestinal reactions,bone marrow suppression,abnormal liver function,renal function damage,peripheral neurotoxicity,and the incidence of adverse reactions of the experiment group was lower than the control group (P<0.05).Conclusion:The Modified Bazhen Decoction with adjuvant therapy of chemotherapy in the treatment of advanced non-small cell lung cancer has curative effects.It can significantly reduce bone marrow suppression,improve immune function and quality of life of the patients,and reduce the toxic and side effects caused by chemotherapy.