To observe the clinical efficacy and pregnancy outcomes and to try to explore and analyze the related mechanism of treatment by treating endometriosis infertility patients with modified Guizhi Fuling Decoction.Methods:A total of 98 patients with endometriosis infertility treated in the Second Affiliated Hospital of Hainan Medical University from January 2016 to January 2017 were selected and randomly divided into the observation group and the control group,with 49 cases in each group.The control group was treated with gestrinone orally while the observation group was given Guizhi Fuling Decoction on the basis of the same treatment.The treatment course of both groups was 3 months.The clinical efficacy of 2 groups of patients was observed after the treatment,and the contents of vascular endothelial growth factor (VEGF),follicle stimulating hormone (FSH),luteinizing hormone (LH),serum estradiol (E2),progesterone (P),tumor necrosis factor-alpha (TNF-a) and carbohydrate antigen 125 (CA125) in both groups were analyzed.A 12-month telephone follow-up was performed on both groups to compare the pregnancy outcomes of each group.Results:The total effective rate of the control group was 71.43%,and the total effective rate of the observation group was 91.84%.The rate of observation group was obviously superior to the control group (P<0.05),and the levels of FSH,LH,E2 and P in both groups were significantly decreased after the treatment (P>0.05).Compared with the control group,there was no significant difference in the levels of FSH and LH between the 2 groups after treatment (P>0.05),and the E2 and P in the observation group decreased more than that of the control group (P<0.05).The levels of VEGF,CA125 and TNF-α in the serum of both groups significantly decreased (P<0.05),and the observation group decreased more than the control group (P<0.05).In both groups of patients,23 patients in the control group had a successful pregnancy in 1 year (pregnancy rate 46.94%),and 38 patients in the observation group had a successful pregnancy (pregnancy rate 77.55%).The pregnancy rate of observation group was better than the control group (P<0.05).Conclusion:Jiawei Guizhi Fuling Decoction can effectively improve the clinical symptoms of infertile patients with endometriosis and improve their pregnancy rate,which may be related to the regulation of hormone and cytokine levels in the patients.