To investigate the effects of Self-made Anxintang Xieding Formula on serum oxidative stress indicators and levels of HCY,D-dimer,LP (a) of patients with coronary heart disease.Methods:A total of 92 patients admitted by Rizhao Hospital of Chinese Medicine from January 2016 to June 2017 were selected and randomly divided into control group and observation group,with 46 cases in each group.Patients in the control group were treated with conventional medicine.Based on the same treatment,patients in the observation group were also treated with Self-made Anxintang Xieding Formula.For comparing the clinical efficacy of both groups,the angina,heart function and electrocardiogram were observed,the oxidative stress indicators were monitored,and serum HCY,D-dimer,LP (a) level were detected.Results:The efficacy rate in the observation group was 91.3%,which was higher than that of the control group (71.7%) (P<0.05).After treatment,the average times and duration of weekly angina pectoris in the observation group was significantly less than that in the control group.Compared with the control group,and the cardiac function index such as the levels of LVEF and LVDD of the observation group were significantly increased,and the myocardial oxygen consumption of observation group significant increased (P<0.05),and the SDNN of patients in the observation group was higher,and the QTd of the observation group was lower (P<0.05).The levels of MAD,HCY,D-D and LP(a) in observation group were lower,while the SOD,GSH-PX and T-Aoc were higher than that of the control group (P<0.05).Conclusion:The Self-made Anxintang Xieding Formula has therapeutic efficiency.Its mechanism is anti-coronary atherosclerosis by the regulation of oxidative stress indicators and serum HCY,D-dimer,LP (a) levels.