To observe the therapeutic effects of Wenyang Tongluo Therapy on cold-dampness obstruction type ankylosing spondylitis (AS).Methods:A total of 60 patients with cold-dampness obstruction type AS treated in Nanjing University of Science and Technology Hospital from January 2016 to March 2017 were selected and randomly divided into observation group and control group,with 30 cases in each group.The control group was treated with conventional method while the observation group was treated with Wenyang Tongluo Therapy on the basis of the same treatment for 3 courses (4 weeks as a course).The clinical effects and the improvement of main clinical indexes (thoracic activity,occipital wall spacing,finger-ground distance,Schober test),AS functional activity score ［Barthol's ankylosing spondylitis activity index (BASDAI),Pap spirometry ankylosing function index (BASFI)］,laboratory test indicators ［ESR,C-reactive protein (CRP),tumor necrosis factor-on index,and interleukin-6 (IL-6)］ were compared before and after treatment.Results:After treatment,the thoracic activity and Schober test score were significantly increased (P<0.05),and the occipital wall spacing and finger-ground distance were significantly decreased (P<0.05).The improvement of the above indicators was more significant in the observation group,and there was a statistically significant difference between the groups (P<0.05).Both BASDAI and BASFI scores decreased significantly after treatment in both groups (P<0.05),and the above scores decreased more significantly after treatment in the observation group,with statistically significant difference between the two groups (P<0.05).After treatment,the levels of ESR,CRP,IL-6 and TNF-were significantly reduced in both groups (P<0.05),and the decrease of the above indicators was more significant in the observation group,with statistically significant difference between the two groups (P<0.05).After treatment,the total effective rate of the observation group was 90.0%,which was significantly higher than 66.7% of the control group,and the difference was statistically significant (P<0.05).Conclusion:The combination of Wenyang Tongluo Therapy and conventional treatment in treating cold-dampness obstruction type AS can inhibit the body inflammatory response of patients,quickly relieve the patient's clinical symptoms and signs,and help to improve the spinal function of patients.