| 引用本文:钱钻好，王荧荧，傅元凤.玉屏风颗粒联合葡萄糖酸锌治疗小儿反复呼吸道感染的临床效果[J].世界中医药,2018,(09):. |
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| 玉屏风颗粒联合葡萄糖酸锌治疗小儿反复呼吸道感染的临床效果 |
| Clinical Randomized Controlled Trail Of Yupingfeng Granules with Zinc Gluconate in the Treatment of Children with Recurrent Respiratory Tract Infection |
| 投稿时间：2018-06-25 |
| DOI：10.3969/j.issn.1673-7202.2018.09.034 |
| 中文关键词: 反复呼吸道感染 玉屏风颗粒 葡萄糖酸锌 免疫功能 炎性反应介质 复发 |
| English Keywords:Recurrent respiratory tract infection Yupingfeng Granules Zinc gluconate Immune function Inflammatory cytokines Recurrence |
| 基金项目:南京大学医学院附属泰康仙林鼓楼医院科研项目（TKKY0716） |
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| 中文摘要: |
| 目的：探究玉屏风颗粒联合葡萄糖酸锌治疗小儿反复呼吸道感染的临床疗效及对炎性反应介质、免疫功能及复发的影响。方法：选取2016年3月至2017年4月南京大学医学院附属泰康仙林鼓楼医院收治的反复呼吸道感染患儿112例，按随机数字表法将其分为对照组与观察组，每组56例。2组患儿均给予常规治疗，对照组同时联合玉屏风颗粒治疗，观察组则在对照组的基础上联合葡萄糖酸锌治疗，2组均连续治疗3个月，并定期随访6个月。统计2组临床疗效及临床症状缓解时间；检测并比较2组治疗前后血清炎性反应介质及免疫功能；随访期间统计2组患儿复发情况，并比较2组治疗期间不良反应发生情况。结果：观察组临床总有效率高达92.86%，较对照组的60.71%升高（P<0.05）；观察组患儿发热、咳嗽、扁桃体红肿等症状消失时间均较对照组患儿缩短（P<0.05）；与治疗前比较，治疗后2组血清白细胞介素-2（IL-2）水平升高，且观察组高于对照组（P<0.05）；治疗后2组血清白细胞介素-6（IL-6）及肿瘤坏死因子-α（TNF-α）水平降低，且观察组低于对照组（P<0.05）；与治疗前比较，治疗后2组血浆IgA、IgG、IgM水平，全血CD4+细胞比例及观察组CD4+/CD8+比值升高（P<0.05）；且观察组血浆IgG、IgM水平，全血CD4+细胞比例及CD4+/CD8+比值高于对照组（P<0.05）；观察组复发率及复发次数均较对照组降低（P<0.05）。治疗及随访期间2组患儿均未见严重不良反应发生。结论：玉屏风颗粒联合葡萄糖酸锌治疗小儿反复呼吸道感染可有效抑制其炎性反应，增强其细胞免疫及体液免疫功能，减少患儿复发，并具有良好的安全性，临床疗效显著优于玉屏风颗粒单用。 |
| English Summary: |
| To explore the clinical efficacy of Yupingfeng Granules combined with Zinc gluconate on children with recurrent respiratory tract infection and the effects on inflammatory cytokines,immune function and recurrence.Methods:A total of 112 children with recurrent respiratory tract infection treated in Taikang Xianlin Drum Tower Hospital Affiliated to Medical School of Nanjing University from March 2016 to April 2017 were selected and divided into control group and observation group according to the random number table method,with 56 cases in each group.Both groups received conventional treatment,and the control group was additionally given Yupingfeng Granules at the same time.The observation group was given Zinc gluconate at the same time.Both groups were treated for 3 months and followed-up for 6 months regularly.The clinical efficacy and the duration of remission of clinical symptoms in both groups were statistically analyzed,and the levels of serum inflammatory cytokines,immune function indexes in both groups were detected and compared before and after treatment.The recurrence times in both groups were compared during followed-up period,and the adverse reactions occurrence in both groups were compared during the treatment and followed-up period.Results:The clinical effective rate in observation group reached up to 92.86%,which was higher than that 60.71% of control group (P<0.01).The disappearance time of the clinical symptoms such as fever,cough,tonsil inflammation in observation group was shorter than those in control group (P<0.01).Compared with before treatment,the serum IL-2 levels in both groups increased after treatment,and observation group increased more than control group (P<0.01).The serum IL-6 and TNF-α levels decreased after treatment,and observation group decreased more than control group (P<0.01).Compared with before treatment,the content of plasma IgA,IgG,IgM,whole blood CD4+ cell proportion in both groups and the CD4+/CD8+ value in the observation group increased after treatment (P<0.05 or P<0.01),and the content of plasma IgA,IgG,IgM,whole blood CD4+ cell proportion and CD4+/CD8+ value in observation group increased more than those in control group (P<0.05 or P<0.01).The recurrence rate and recurrent times in the observation group were decreased more than those in control group (P<0.01).There was no significant adverse reactions occurrence during treatment and followed-up in both groups.Conclusion:The combination of Yupingfeng Granules and Zinc gluconate in the treatment of children with recurrent respiratory tract infection can inhibit the inflammatory reaction,enhance the cellular immunity and humoral immunity function,and reduce the recurrence of children.It is safe,and its clinical efficacy is better than only treating with Yupingfeng Granules. |
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