To explore the clinical efficacy of Yupingfeng Granules combined with Zinc gluconate on children with recurrent respiratory tract infection and the effects on inflammatory cytokines,immune function and recurrence.Methods:A total of 112 children with recurrent respiratory tract infection treated in Taikang Xianlin Drum Tower Hospital Affiliated to Medical School of Nanjing University from March 2016 to April 2017 were selected and divided into control group and observation group according to the random number table method,with 56 cases in each group.Both groups received conventional treatment,and the control group was additionally given Yupingfeng Granules at the same time.The observation group was given Zinc gluconate at the same time.Both groups were treated for 3 months and followed-up for 6 months regularly.The clinical efficacy and the duration of remission of clinical symptoms in both groups were statistically analyzed,and the levels of serum inflammatory cytokines,immune function indexes in both groups were detected and compared before and after treatment.The recurrence times in both groups were compared during followed-up period,and the adverse reactions occurrence in both groups were compared during the treatment and followed-up period.Results:The clinical effective rate in observation group reached up to 92.86%,which was higher than that 60.71% of control group (P<0.01).The disappearance time of the clinical symptoms such as fever,cough,tonsil inflammation in observation group was shorter than those in control group (P<0.01).Compared with before treatment,the serum IL-2 levels in both groups increased after treatment,and observation group increased more than control group (P<0.01).The serum IL-6 and TNF-α levels decreased after treatment,and observation group decreased more than control group (P<0.01).Compared with before treatment,the content of plasma IgA,IgG,IgM,whole blood CD4+ cell proportion in both groups and the CD4+/CD8+ value in the observation group increased after treatment (P<0.05 or P<0.01),and the content of plasma IgA,IgG,IgM,whole blood CD4+ cell proportion and CD4+/CD8+ value in observation group increased more than those in control group (P<0.05 or P<0.01).The recurrence rate and recurrent times in the observation group were decreased more than those in control group (P<0.01).There was no significant adverse reactions occurrence during treatment and followed-up in both groups.Conclusion:The combination of Yupingfeng Granules and Zinc gluconate in the treatment of children with recurrent respiratory tract infection can inhibit the inflammatory reaction,enhance the cellular immunity and humoral immunity function,and reduce the recurrence of children.It is safe,and its clinical efficacy is better than only treating with Yupingfeng Granules.