| 引用本文:张怡，伏小琳，刘博，李康，谭辉.加味麻杏石甘汤治疗重症肺炎的临床疗效及其对肺功能、HMGB1水平的影响[J].世界中医药,2018,(09):. |
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| 加味麻杏石甘汤治疗重症肺炎的临床疗效及其对肺功能、HMGB1水平的影响 |
| Clinical Curative Effect of Modified Maxing Shigan Decoction on Severe Pneumonia and Its Effects on Pulmonary Function and the Level of HMGB1 |
| 投稿时间：2018-04-23 |
| DOI：10.3969/j.issn.1673-7202.2018.09.035 |
| 中文关键词: 麻杏石甘汤 重症肺炎 肺功能 HMGB1 血清炎性反应因子 |
| English Keywords:Modified Maxing Shigan Decoction Severe pneumonia Pulmonary function HMGB1 Serum inflammatory cytokines |
| 基金项目:陕西省科技计划项目(2014K11-01-01-13) |
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| 中文摘要: |
| 目的:观察加味麻杏石甘汤治疗重症肺炎的临床疗效及其对肺功能、血清炎性反应因子、红细胞分布宽度、红细胞体积及HMGB1水平的影响。方法:选取2016年2月至2018年2月咸阳市中心医院收治的重症肺炎患者146例,按随机数字表法分为对照组和观察组,每组73例。对照组给予西药抗感染、止咳祛痰、退热等对症处理,观察组在对照组治疗的基础上给予麻杏石甘汤,观察2组临床疗效、肺功能、血清炎性反应因子(WBC、PCT、CRP、TNF-α)、前白蛋白、RDW、MCV、HMGB1变化情况。结果:经过治疗后,2组肺功能(PImax、PEmax、MMF、PEF)、前白蛋白明显升高,血清炎性反应因子(WBC、PCT、CRP、TNF-α)水平、RDW、MCV、HMGB1明显降低,观察组上述指标变化更明显,差异有统计学意义(P<0.05)。观察组的治疗总有效率(91.41%)明显高于对照组(64.38%),差异有统计学意义(P<0.05)。结论:加味麻杏石甘汤治疗重症肺炎可改善肺功能,降低血清炎性反应因子、前白蛋白、HMGB1水平,降低红细胞分布宽度及红细胞体积,从而提高临床治疗效果。 |
| English Summary: |
| To observe the clinical curative effect of Modified Maxing Shigan Decoction in the treatment of severe pneumonia and its effects on lung function,the serum level of inflammatory cytokines,red blood cell distribution width,red blood cell volume and the level of HMGB1.Methods:A total of 146 patients with severe pneumonia treated in Xianyang Central Hospital from February 2016 to February 2017 were selected and divided into control group and observation group according to the random table method,with 73 cases in each group.The control group was given western medicine for anti-infection,relieving cough and eliminating phlegm,bringing down fever.The observation group was given Modified Maxing Shigan Decoction based on the same treatment of the control group.The clinical effect,pulmonary function,the level of serum inflammatory factors (WBC,PCT,CRP,TNF-α),prealbumin,RDW,MCV,HMGB1 of both groups were observed.Results:After treatment,the pulmonary function indicators (PImax,PEmax,MMF,PEF),prealbumin of two groups increased significantly (P<0.05),and the level of serum inflammatory cytokines (WBC,PCT,CRP,TNF-α),RDW,MCV,HMGB1 decreased obviously.The above indexes changed more obviously in the observation group.The differences were statistically significant (P<0.05).The total effective rate of the observation group was (91.41%) which was obviously higher than that of the control group (64.38%),and the difference was statistically significant (P<0.05).Conclusion:Modified Maxing Shigan Decoction in the treatment of severe pneumonia can improve lung function,reduce the level of serum inflammatory factors,prealbumin,HMGB1,red blood cell distribution width and red blood cell volume to improve the clinical therapeutic effect. |
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