To explore the clinical efficacy of Traditional Chinese Medicine (TCM) with NB-UVB on vitiligo and the effects on immune function in patients.Methods:A total of 98 patients with vitiligo treated in Hainan Skin Disease Hospital from April 2014 to October 2016 were selected and randomly divided into control group and observation group.Both groups received NB-UVB treatment,and observation group was additionally given Baibo Decoction for 3 months.The clinical efficacy of the 2 groups was statistically analyzed,and the improvement of the area of vitiligo before and after treatment was compared between the 2 groups.The proportion of T lymphocyte subsets and the expression levels of GM-CSF,IFN-prond IL-4 in the 2 groups before and after treatment were detected and compared,and Th1/Th2 was calculated.Results:The total effective rate was 81.63% in observation group after treatment,which was significantly higher than 61.22% of control group (P<0.05).The area of vitiligo lesions in both groups decreased after treatment,and the observation group decreased more significantly than the control group (P<0.01).After treatment,the proportion of CD4+,CD4+CD25+Treg cells and the ratio of CD4+/CD8+ in both groups were increased,and the proportion of CD8+ cells and the content of GM-CSF were decreased (P<0.05 or P<0.01).The difference between the 2 groups was significant (P<0.01).After treatment,serum IL-4 content increased,and IFN-gamma content and Th1/Th2 ratio decreased in both groups (P<0.01).Conclusion:TCM combined with NB-UVB is effective in treating vitiligo,which can improve the immune function of patients,regulate the expression of related cytokines and delay the progression of the disease,which is safe and effective.