To observe the clinical efficacy of Chaihu Jia Longgu Muli Decoction in the treatment of epilepsy resulted from cerebral apoplexy,and to evaluate the effects of peripheral blood neuron specific enolase (NSE) concentration.Methods:A total of 50 cases patients with epilepsy resulted from cerebral apoplexy treated in the First Clinical Medicine College of Shandong University of Traditional Chinese Medicine from January 2015 to September 2016 were selected and randomly divided into control group and observation group,with 25 cases in each group.Both groups received conventional treatment in neurology,and the control group was supplemented with sodium valproate sustained-release tablets.On the basis of the treatment plan of the control group,the observation group was given Chaihu Jia Longgu Muli Decoction one dose a day (200 mL decocted as one dose),and the dose was taken separately in the morning and evening with warm water.The two groups were treated for 16 weeks.The clinical efficacy,limb motor function score,seizure frequency,duration of attack,electroencephalogram and NSE concentration of both groups were observed before and after treatment.Results:After the treatment,the total clinical efficiency rate of the observation group was 88%.Compared with the rate of the control group (68%),the difference was statistically significant (P<0.05),and the rate of observation group was better than the control group.After the 4th week of treatment,there was no statistically significant difference in the Fugl-Meyer score,WOLF score and BBS score of both groups (P>0.05).Until the 16th week of treatment,the Fugl-Meyer score,WOLF score and BBS score of observation group were better than the control group (P<0.05).After the treatment,the frequency and duration of seizure of patients in both groups decreased,and the observation group decreased more significantly than the control group (P<0.05).At the 4th week treatment,epileptiform discharges,involving the number of leads in both groups were no statistically significant (P>0.05),and until 16th week of treatment,the improvement of curative efficacy of observation group was better than control group (P<0.05).There was no statistical significance of peripheral blood NSE concentration in the both groups at the 4th week (P>0.05).Until the 16th week of treatment,the peripheral blood NSE concentration of the observation group decreased more significantly than the control group (P<0.05).Conclusion:Chaihu Jia Longgu Muli Decoction has an effective curative effect on epilepsy resulted from cerebral apoplexy,and its mechanism may be related to the decrease of NSE concentration in peripheral blood.