To investigate the effects of Shouhui Tongbian Capsule on intestine pushing rate and colonic mucus secretion in slow transit constipation model animals,and to explore the correlating mechanism of Shouhui Tongbian Capsule on slow transit constipation.Methods:The rat model of slow transit constipation was established by intragastric administration with compound diphenoxylate tablet and water restriction.The model rats were randomly divided into control group,Shouhui Tongbian Capsule high,middle,low dose groups and Qirong Runchang Oral Liquid.The pushing rate of intestine,the time of first black stool discharge and the number of fecal particles in 12 h in compound difenolate (DC) constipation model rats were observed.Cecocolon sections removed by ligation were fixed and paraffin sections were prepared and stained with AB-PAS for histological observation.Results:Compared with the control group,Shouhui Tongbian Capsule significantly reduced the time of first black stool discharge,increased the intestine pushing rate (P<0.05).Meanwhile,the black stool points in 12 h increased (P<0.05) in the constipation model rats which were induced by compound diphenoxylate tablets.The number of mucous cells in the colonic mucosa of rats in medium and high dose Shouhui Tongbian Capsule groups increased significantly,and compared with the model group,the difference was statistically significant (P<0.05).Conclusion:Shouhui Tongbian Capsule can improve intestinal motility,increasing mucus secretion of colon to effectively improve constipation symptoms and improve the quality of life of patients.