To observe the clinical curative effect of electro-acupuncture combined with pelvic floor muscle training on postpartum pelvic organ prolapse, and to analyze part of the action mechanism. Methods:A total of 60 cases of patients with postpartum pelvic organ prolapse in our hospital from January 2016 to January 2017 were included in the study and randomly divided into the control group and the observation group, with 30 cases in each group. Both of the two groups of patients had pelvic floor muscle training. The observation group had electro-acupuncture on the basis of the treatment, 30 min/times, five times per week, 20 times for a course of treatment. Both of the two groups accepted 2 courses of treatment, and the treatment had 2 d interval. TCM syndrome integrals, quality of life scores (PFIQ-7), urinary incontinence symptom scores (ICIQ-SF), pelvic floor muscle assessment and TGF-β1 concentration changes of two groups before and after treatment were compared. Results:1)TCM syndrome integrals in the two groups of patients declined after treatment, and the observation group was better than that of the control group (P<0.05); 2)Total scores of PFIQ-7 and ICIQ-SF in the two groups were significantly lower than before treatment (P<0.05), and the downward trend in the observation group was more obvious. 3)The maximal contractile force and contraction duration of the pelvic floor were significantly improved after treatment, and there was significant difference between the two groups (P<0.05). The observation group was better than the control group. 4)Compared with the control group, electro-acupuncture combined with pelvic floor muscle training obviously increased TGF-β1 level in the postpartum pelvic organ prolapse, and the differences were statistically significant (P<0.05). Conclusion:Electro-acupuncture combined with pelvic floor muscle training can effectively improve the pelvic floor muscle strength, reduce the occurrence of urinary incontinence, and improve the life quality of patients. The mechanism may be related with the up-regulation of TGF-β1 concentration.