| 引用本文:孙晓东，杨宁，车文生.针刺治疗脑卒中后抑郁患者的疗效及对神经营养状态、单胺类神经递质的影响[J].世界中医药,2018,(09):. |
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| 针刺治疗脑卒中后抑郁患者的疗效及对神经营养状态、单胺类神经递质的影响 |
| Curative Effects of Acupuncture on Post-stroke Depression and its Effects on Neurotrophic Status and Monoamine Neurotransmitters |
| 投稿时间：2017-09-23 |
| DOI：10.3969/j.issn.1673-7202.2018.09.046 |
| 中文关键词: 脑卒中后抑郁 针刺 神经营养状态 脑源性神经营养因子 胰岛素样生长因子-1 单胺类神经递质 多巴胺 去甲肾上腺素 |
| English Keywords:Post-stroke depression acupuncture Neurotrophic status Brain derived neurotrophic factor Insulin like growth factor-1 Monoamine neurotransmitter Dopamine Norepinephrine |
| 基金项目:2017年度河南省医学科技攻关计划项目(201702265) |
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| 中文摘要: |
| 目的：探讨针刺治疗脑卒中后抑郁患者的疗效及对神经营养状态、单胺类神经递质的影响。方法：选取2015年1月至2017年1月郑州人民医院收治的脑卒中后抑郁患者78例，按照随机数表法随机分为对照组和观察组，每组39例。对照组患者接受常规治疗，观察组患者接受常规治疗＋针刺治疗，持续1个月。比较2组患者治疗前后病情评分、血清神经营养指标及单胺类神经递质水平的差异。结果：治疗前，2组患者中国脑卒中患者临床神经功能缺损评分标准（CSS）、汉密尔顿抑郁量表（HAMD）评分值，血清中神经营养指标及单胺类神经递质水平的差异无统计学意义（P>0.05）。治疗1个月后，观察组患者的CSS、HAMD评分值低于对照组患者；观察组患者血清中脑源性神经营养因子（BDNF）、神经生长因子（NGF）的水平高于对照组患者，胰岛素样生长因子-1（IGF-1）的水平低于对照组患者；观察组患者血清中多巴胺（DA）、去甲肾上腺素（NE）、5-羟色胺（5-HT）的水平高于对照组患者（P<0.05）。结论：脑卒中后抑郁患者接受针刺辅助治疗，可有效优化病情、改善神经营养状态、提升单胺类神经递质表达。 |
| English Summary: |
| To study the effects of acupuncture on post-stroke depression and its effects on neurotrophic status and monoamine neurotransmitters.Methods:A total of 78 cases of post-stroke depression patients in our hospital during January 2015 to 2017 January were chosen as research subject.All patients were randomly divided into control group and observation group, with 39 cases in each group.Patients in control group were treated with routine treatment, and those in observation group were treated with conventional treatment plus acupuncture treatment.Both treatments lasted for one month.The disease score, serum neurotrophic indexes and monoamine neurotransmitters were compared between two groups before and after treatment.Results:Before treatment, there were no significant difference between two groups in the scores of CSS and HAMD, serum contents of neurotrophic indexes and monoamine neurotransmitters (P>0.05).One month after treatment, CSS, HAMD scores in observation group were lower than those in control group; serum contents of BDNF and NGF in observation group were higher than those in control group, and IGF-1 was lower than that in control group; serum contents of monoamine neurotransmitters such as DA, NE, 5-HT were higher than those in control group (P<0.05).Conclusion:The treatment of acupuncture in patients with post-stroke depression can effectively optimize the condition, improve the neurotrophic status and enhance the monoamine neurotransmitter expression. |
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