To study the effects of acupuncture on post-stroke depression and its effects on neurotrophic status and monoamine neurotransmitters.Methods:A total of 78 cases of post-stroke depression patients in our hospital during January 2015 to 2017 January were chosen as research subject.All patients were randomly divided into control group and observation group, with 39 cases in each group.Patients in control group were treated with routine treatment, and those in observation group were treated with conventional treatment plus acupuncture treatment.Both treatments lasted for one month.The disease score, serum neurotrophic indexes and monoamine neurotransmitters were compared between two groups before and after treatment.Results:Before treatment, there were no significant difference between two groups in the scores of CSS and HAMD, serum contents of neurotrophic indexes and monoamine neurotransmitters (P>0.05).One month after treatment, CSS, HAMD scores in observation group were lower than those in control group; serum contents of BDNF and NGF in observation group were higher than those in control group, and IGF-1 was lower than that in control group; serum contents of monoamine neurotransmitters such as DA, NE, 5-HT were higher than those in control group (P<0.05).Conclusion:The treatment of acupuncture in patients with post-stroke depression can effectively optimize the condition, improve the neurotrophic status and enhance the monoamine neurotransmitter expression.