To study the efficacy of warm acupuncture and moxibution on Yanglingquan (GB 34) combined with isokinetic training on patients with knee osteoarthritis and effects on VAS and Lysholm knee score. Methods:A total of 80 patients with knee osteoarthritis were selected from February 2015 to July 2016 in our hospital. According to random number table, the cases were divided into observation group and control group with 40 cases in each group. The control group received isokinetic training treatment, and observation group was treated with moxibustion GB 34 treatment based on the control group. The clinical curative effect of two groups VAS and Lysholm knee score before and after treatment, knee flexion and extension of the changes were compared. Results:The total effective rate of observation group was 92.50% (37/40), higher than that of the control group, 75% (30/40), with a significant difference (P<0.05). After treatment, the VAS scores of the two groups were lower than those before treatment, and the observation group was lower than the control group, with significant difference (P<0.05). Lysholm knee score of two groups was lower than that before treatment, and the observation group was lower than the control group, with significant difference (P<0.05). After treatment, the knee flexion and extension of observation group were respectively (120.4±17.9)%, (-3.1±0.8)%, higher than those of control group (92.5±5.9)%, (-6.0±1.1)%, with significant difference (P<0.05). Conclusion:The clinical efficacy of acupuncture moxibustion GB 34 combined isokinetic training in the treatment of knee osteoarthritis is significant, which can effectively relieve the pain of patients, promote the functional recovery of the knee joint.