To compare the fingerprints of Gegen Qinlian Formula granules and its traditional decoction by high performance liquid phase (HPLC).Methods:Gegen Qinlian Decoction Formula granules and traditional decoctions from 3 different hospitals A,B,C,were selected.After preparing the control solution and test solution,the HPLC fingerprint analysis was carried out under the optimized chromatographic conditions.Results:The results of HPLC intermediate precision test,repeatability test and stability test were all good.Gegen Qinlian Decoction granules HPLC fingerprint showed that the spectra of K1,K2 and K3 differed greatly during the first 5 min.Then after the 5 min,HPLC fingerprint of Gegen Qinlian Decoction Formula granules from 3 different hospitals had 10 similar characteristic peaks,the content of K3 characteristic peak was quite different from K1 and K2,especially No.1 and No.4 peaks.In comparison of K1 and T1,K2 and T2,K3 and T3 of granules and traditional decoctions,the content of the characteristic peak of granules was higher than that of traditional decoctions.Conclusion:There are certain differences in the HPLC fingerprints of Gegen Qinlian Decoction granules and traditional decoction from different hospitals.