To analyze the characteristics and principles of syndrome differentiation treatment by Professor Shi Dazhuo in coronary heart disease (CHD) after percutaneous transluminal coronary intervention (PCI) with complex network analysis method.Methods:The syndromes and TCM information of CHD after PCI by Professor Shi through TCM clinical information platform of CHD were collected,and the network node which includes Chinese herbs,syndromes and efficacy was used to build the complex network structure of Chinese herbs-Chinese herbs,syndrome-Chinese herbs and efficacy-efficacy.Results:The complicated network analysis of Chinese herbs-Chinese herbs showed that the main Chinese herb node including Radix Salviae Miltiorrhizae,Radix Astragali seu Hedysari,Rhizoma Ligustici Chuanxiong,Rhizoma Curcumae,Radix Paeoniae Rubra,Rhizoma Coptidis,Radix Notoginseng,Flos Lonicerae.The complicated network analysis of syndrome-Chinese herbs showed that the main Chinese herb nodes corresponding to blood stasis were Radix Paeoniae Rubra,Radix Salviae Miltiorrhizae,Rhizoma Curcumae,Rhizoma Ligustici Chuanxiong,Flos Carthami,and Radix Notoginseng.The main Chinese herb nodes corresponding to qi deficiency were Radix Astragali seu Hedysari,Radix Codonopsis,Radix Panacis Quinquefolii.The main Chinese herb nodes corresponding to phlegm were Fructus Trichosanthis,Bulbus Allii Macrostemonis,Rhizoma Pinelliae,Pericarpium Cirri Reticulatae,Poria.The main Chinese herb nodes corresponding to pyretic toxicity were Rhizoma Coptidis,Flos Lonicerae and Radix Astragali seu Hedysari.The analysis of complex network of efficacy-efficacy showed that the main efficacy node contained activating blood circulation,clean heat,stopping pain and calm nerves.Conclusion:Professor Shi is likely to apply benefiting qi for activating blood circulation and detoxifying medicine to treat patients with CHD after PCI.The key materials in his prescription Radix Salviae Miltiorrhizae,Radix Astragali seu Hedysari,Rhizoma Ligustici Chuanxiong,Rhizoma Curcumae,Radix Paeoniae Rubra,Rhizoma Coptidis,Radix Notoginseng,Flos Lonicerae..