To investigate the effect of intervention of discharge prescriptions on the integrated traditional Chinese and western medicine on clinical medication.Methods:The combination prescriptions of traditional Chinese and western medicine of one hospital were selected from January to December in 2017.The rationality of the prescription was investigated in terms of indication,dosage,compatibility and contraindications,and clinical medication intervention was used for the irrational prescription to correct its irrationality.The unqualified rate of prescriptions before and after intervention was compared as the observation indexes,and the main problems of irrational prescriptions were analyzed.Results:A total of 3 056 prescriptions were analyzed,and the unqualified rate of prescriptions was 3.99% (122/3 056).The problems of irrational prescriptions were nonstandard and improper drug use.There were 91 (74.59%) non-standard prescriptions,and the characteristics were too illegible for the pharmacist to recognize,and the signature of the doctors was abbreviated and sketched,which easily led to confusion between prescriptions of doctors with the same family name.There were 31 prescriptions of improper drug use,accounting for 25.41% (31/122),and the main problems were that the dosage of drugs did not conform to the instructions,and the cost of single prescription exceeded the settlement amount of medical insurance.The combination of Chinese and western medicine is unreasonable,and some functions in Chinese and western medicine overlapped.After clinical intervention,the unqualified prescription rate was 1.05% (32 / 3 056).The difference of unqualified rate of prescriptions before and after intervention was statistically significant (χ2=19.170,P=0.000<0.05),which indicated that the rate of unqualified prescriptions was effectively reduced by clinical intervention.Conclusion:It is necessary to improve the level of rational use of drugs and to ensure the safety of drug use in patients.