世界中医药
文章摘要
引用本文:符丽,曾金妹,林琳.间质性肺疾病的临床特征及中医证候[J].世界中医药,2018,(09):.  
间质性肺疾病的临床特征及中医证候
Analysis of Clinical Features and Traditional Chinese Medicine Syndrome with Interstitial Lung Disease
投稿时间:2017-06-30  
DOI:10.3969/j.issn.1673-7202.2018.09.058
中文关键词:  间质性肺疾病  临床表现  检查特点  疾病特征  证候分型  回顾性分析
English Keywords:Interstitial lung disease  Clinical manifestation  Examination feature  Disease characteristics  Syndrome type  Elements of disease location  Elements of disease nature  Retrospective analysis
基金项目:广东周仲瑛学术经验传承工作室(2014-89-3)
作者单位
符丽,曾金妹,林琳 广东省中医院呼吸内科广州510120 
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中文摘要:
      目的:探讨间质性肺疾病的临床特点、证候分型及证候要素分布特点。方法:选取2012年12月至2015年11月于广东省中医院大德路总院呼吸科住院的间质性肺疾病患者37例(其中18例为特发性间质性肺疾病,19例为继发性间质性肺疾病),回顾性分析其临床资料及血气分析、凝血功能、病原学检测、肺功能、胸部高分辨CT(HRCT)等检查资料,并对特发性与继发性间质性肺疾病2组资料进行初步比较。结果:间质性肺疾病患者临床以咳嗽、气促伴肺部Velcro音为主要表现;血气分析主要表现为过度通气、低氧血症及I型呼吸衰竭;肺功能多数呈限制性通气功能和弥散障碍;HRCT在影像学上主要显示双肺网格状、蜂窝状、斑片状、索条状影及小叶间隔增厚,部位主要分布于双肺下叶胸膜下及双肺散在;病原学检查显示,以合并支原体感染最多,其次为真菌;以抗氧化及糖皮质激素治疗为主;病性证素:痰>瘀>热>气虚>阴虚,病位证素:脾>肺>肾>肝,其中病性证素“瘀”与现代医学实验室检查中FIB之间的相关性有统计学意义(P<0.05),辨证分型以“肺脾肾虚,痰热瘀阻”“气阴两虚,痰瘀内阻”“气虚痰瘀阻络”3型所占比例较多。特发性间质性肺疾病组18例与继发性间质性肺疾病组19例,临床症状2组比较,气促发生率差异有统计学意义(18/18比15/19,P<0.05),35例行HRCT检查,病灶主要分布于双肺下叶胸膜下、双肺散在、双肺胸膜下及双下肺,双下肺2组发生率差异有统计学意义(4/17比0/18,P<0.05)。结论:间质性肺疾病的诊断主要根据典型临床表现,结合血气分析、肺功能、HRCT等实验室及辅助检查,胸部影像学尤其HRCT能及早确定病变性质和范围。中医证候分型以“肺脾肾虚,痰热瘀阻”“气阴两虚,痰瘀内阻”“气虚痰瘀阻络”3型相对较多,病位证素以脾、肺多见,病性证素以痰、瘀多见。
English Summary:
      To investigate the clinical characteristics of interstitial lung disease and the diagnostic value of the examination results, and to preliminarily analyze the characteristics of syndrome types and distribution characteristics of the syndrome elements.Methods:A retrospective analysis of the clinical data of 37 cases with interstitial lung disease (18 cases with idiopathic interstitial lung disease and 19 cases with secondary interstitial lung disease) who were admitted in our hospital from December 2012 to November 2015 and test data of blood gas analysis, coagulation, etiology, lung function, chest high resolution CT (HRCT) were conducted.And the data of idiopathic and secondary interstitial lung disease were compared.Results:1) Patients with interstitial lung disease were manifested with cough, shortness of breath and lung Velcro.2) The main manifestations of blood gas analysis were over ventilation, hypoxia and type I respiratory failure.3) The majority of lung function showed restrictive ventilation function and diffusion barrier.4) HRCT showed grid, honeycomb, patchy, strip shadow and interlobular septal thickening in the imaging position, mainly distributed in the lung by the pleura and lung scattered.5) The pathogenic examination showed that the mycoplasma infection was the most, followed by fungi.6) Primary treatment was antioxidant and glucocorticoid hormone.7) Syndrome factors of disease:phlegm>stasis>heat>Qi deficiency>Yin deficiency; Syndrome elements of disease location:spleen>lung>kidney>liver, of which the correlation between syndrome elements “blood stasis” and FIB in the laboratory of modern medicine had statistical significance (P<0.05).The proportion of the three types of syndrome were more including “lung spleen and kidney deficiency, phlegm heat and blood stasis”, “qi and yin deficiency, phlegm and blood stasis internal obstruction”, “qi deficiency, phlegm and blood stasis obstructing the collateral”.8) Compared between 18 patients with idiopathic interstitial lung disease and 19 cases with secondary interstitial lung disease, the difference of the rate of shortness of breath rate (18/18 vs 15/19) was statistically significant (P<0.05).HRCT examination was carried out in 35 cases.The lesions were mainly distributed in the lower lobe of the lung, double-lung, under the double lung and both lower lung.There were statistically significant differences in the incidence of both lower lung (4/17 vs 0/18) between two groups (P<0.05).Conclusion:The diagnosis of interstitial lung disease is mainly based on the typical clinical manifestations, combined with blood gas analysis, pulmonary function, HRCT and other laboratory and auxiliary examination.Chest imaging, especially HRCT, can determine the nature and extent of the lesion as early as possible, with positive clinical significance to the early diagnosis.TCM syndrome type with “lung spleen and kidney deficiency, phlegm heat and blood stasis”, “qi and yin deficiency, phlegm and blood stasis internal obstruction”, “qi deficiency, phlegm and blood stasis obstructing the collateral” are relatively more.The spleen and lung disease syndrome is more common.The disease syndromes are phlegm and blood stasis.
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