Yupingfeng powder is composed of Radix Astragali seu Hedysari, Rhizoma Atractylodis Macrocephalae and Radix Saposhnikoviae, and has the effects of strengthening vital qi and consolidation of exterior.It has been widely used in the clinical practice, and has great development and application value.Consulting relevant literatures on Yupingfeng powder as prevention and treatment of liver disease in recent years, the mechanism, clinical application and pharmacological research of liver disease be prevented and treated by individual components and the whole of Yupingfeng powder have been summarized.It is confirmed that Yupingfeng powder has the functions of regulating immunity, anti-oxidation, anti-fibrosis and anti-tumor in the prevention and treatment of liver diseases.