| 引用本文:卢幼然2，狄浩然1,2，丁军颖2,3，郭玉红2,3,4，刘清泉2,3,4.脓毒症免疫失衡机制及中医治疗[J].世界中医药,2018,(09):. |
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| 脓毒症免疫失衡机制及中医治疗 |
| Mechanism of Immunologic Dissonance in Sepsis and the Progress of Traditional Chinese Treatment |
| 投稿时间：2017-07-20 |
| DOI：10.3969/j.issn.1673-7202.2018.09.063 |
| 中文关键词: 脓毒症 免疫失衡 高迁移率族蛋白B1 受体 中医药 免疫调节 信号转导通路 治疗进展 |
| English Keywords:Sepsis Immunologic dissonance HMGB1 Receptor Traditional Chinese medicine Immunomodulation Signal transduction pathways Progress of treatment |
| 基金项目:北京市医院管理局重点医学专业发展计划专项（ZYLX201611）；国家自然科学基金委员会资助项目（81673934） |
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| 中文摘要: |
| 脓毒症高致死率使其成为人类健康的重大威胁，其发病机制尚未完全明确，已知免疫失衡是其主要发病机制之一。高迁移率族蛋白B1(High Mobility Group Box1 Protein，HMGB1)是致免疫失衡的关键因子，有RAGE、TLRs和CD24等多种受体，可通过与受体结合，介导多种信号转导通路，从而发挥免疫调节功能。中药以单体和复方治疗脓毒症均取得一定进展，有待进一步结合现代医学共同应对脓毒症挑战。 |
| English Summary: |
| The high fatality rate of sepsis has become a major threat to human health, and its pathogenesis has not been fully defined. Now we know immunologic dissonance is one of the main pathogenesis of sepsis. HMGB1 is a key factor for the immune imbalance. There are many kinds of receptors, such as RAGE, TLRs and CD24, which can mediate various signal transduction pathways by binding to the receptors, thus giving play to the immunomodulation function. The treatment of sepsis by traditional Chinese medicine single and compound has made some progress, and it remains to be further combined with modern medicine to cope with the challenges of sepsis. |
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