世界中医药

目的:探究热速清颗粒联合阿莫西林对外感发热患者的临床疗效及炎性反应的影响。方法:选取2016年1月至2017年12月安徽省立医院收治的外感发热患者78例，随机分为对照组和观察组，每组39例。对照组患者给予阿莫西林常规治疗，观察组则在对照组的基础上联合热速清颗粒治疗，连续治疗72 h后评价2组疗效。治疗后统计2组临床总有效率；比较2组治疗前后临床症状，体温及血清炎性反应指标变化；统计2组治疗期间不良反应发生情况。结果:与治疗前比较，治疗72 h后2组患者主症、次症及中医证候总积分均降低，且观察组低于对照组（P<0.05）；观察组退热起效时间及完全退热时间均较对照组缩短（P<0.05）；治疗72 h后观察组临床总有效率高达94.87%，较对照组的61.54%升高（P<0.05)；与治疗前比较，治疗12~72 h 2组体温及血清C反应蛋白（CRP）水平均逐渐降低（P<0.05），且治疗24、48、72 h后观察组体温低于对照组（P<0.05），治疗48、72 h后观察组血清CRP水平较对照组降低（P<0.05）；2组治疗期间均未见严重不良反应发生。结论:热速清颗粒联合阿莫西林可有效改善外感发热患者临床症状，快速降低患者体温，并抑制机体炎性反应，同时具有良好的安全性，临床疗效优于阿莫西林单用。

English Summary:

To study the effects of Resuqing Granules combined with amoxicillin in the treatment of exogenous fever and the influence on inflammatory reaction.Methods:A total of 78 patients with exogenous fever in Anhui Provincial Hospital from January 2016 to December 2017 were selected and divided randomly into control group and study group,with 39 cases in each group.Control group was treated with amoxicillin conventional therapy,and study group was treated with Resuqing Granules combined with amoxicillin,and the therapeutic effect evaluation of 2 groups were carried out 72 h after continuous treatment.The clinical effects in 2 groups after treatment were calculated.The improvement of clinical symptoms,the body temperature and serum inflammatory reaction index levels in 2 groups before and after treatment were compared; the occurrence of adverse reactions in 2 groups during the treatment were calculated.Results:Compared with before treatment,the total scores of primary symptoms,secondary symptoms and traditional chinese medicine (TCM) symptoms decreased significantly in 2 groups 72 h after treatment,and the score of study group was lower than that of control group (P<0.01); the antifebrile effect time and completely antifebrile time in study group were shorter than those in control group (P<0.01); the clinical total effective rate in study group 72 h after treatment reached up to 94.87%,which was higher than 61.54% in control group (P<0.01); compared with before treatment,the body temperature and serum CRP levels in 2 groups 12-72 h after treatment decreased gradually (P<0.01),and the body temperature in study group of 24 h,48 h,and 72 h after treatment were lower than those in control group (P<0.05 or P<0.01),and the serum CRP levels in study group of 48 h and 72 h after treatment were lower than those in control group (P<0.01); there was no severe adverse reactions in 2 groups during treatment.Conclusion:Resuqing Granules combined with amoxicillin can improve the clinical symptoms of exogenous fever patients effectively,reduce the body temperature of patients quickly,and inhibit the body inflammatory reaction and has good security,and the clinical effect is better than using amoxicillin alone.

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