世界中医药

目的：观察扶正固本中药汤剂对局部晚期宫颈癌同步放化疗患者的增效减毒作用及对免疫功能的影响。方法：选取2013年1月至2016年1月渭南市妇幼保健院诊治的局部晚期宫颈癌患者81例，根据入组的先后顺序分为观察组（n＝41）和对照组（n＝40）。对照组给予同步放化疗治疗，观察组在放化疗的基础之上给予扶正固本中药汤剂内服。比较2组近期临床疗效、不良反应发生情况及免疫功能。结果：治疗后，观察组总有效率78.05%，显著高于对照组的60.00%（P<0.05）；观察组白细胞减少、血小板减少的总不良反应发生率和胃肠道Ⅲ~Ⅳ反应发生率显著低于对照组（P<0.05）；肝功能损伤、慢性放射性肠炎、慢性放射性膀胱炎发生率与对照组比较，呈下降趋势，但差异无统计学意义（P>0.05）；治疗前2组CD3+、CD4+、CD8+水平及CD4+/CD8+比较，差异均无统计学意义（P>0.05）；治疗后，2组CD3+、CD4+、CD8+水平均较治疗前显著降低（P<0.05），观察组CD3+、CD4+水平和CD4+/CD8+水平均显著高于对照组（P<0.05），CD8+水平低于对照组（P<0.05）。结论：扶正固本中药汤剂内服可提高局部晚期宫颈癌同步放化疗患者的近期临床疗效，减轻不良反应，提高患者的免疫功能。

English Summary:

To investigate the effect of Fuzheng Guben Decoction on synergistic attenuation and immune function of patients with locally advanced cervical cancer undergoing concurrent chemoradiotherapy.Methods:A total of 81 cases of patients with locally advanced cervical cancer in Weinan Maternity and Child Health Care Hospital from January 2013 to January 2016 were selected and divided into control group (n＝40,concurrent chemoradiotherapy only) and observation group (n＝41,concurrent chemoradiotherapy combined with oral administration of Fuzheng Guben Decoction).The clinical efficacy,occurrence of adverse reactions and immune function were compared between the two groups.Results:After treatment,the total effective rate of the observation group were significantly higher than that of the control group (78.05% vs 60.00%) (P<0.05); The incidence of leukopenia,the total adverse reactions to thrombocytopenia,and gastrointestinal Ⅲ-Ⅳ reactions of the observation group were significantly lower than that of the control group (P<0.05).Liver function injury,chronic radiation enteritis,and chronic radiation cystitis showed a decreasing trend compared with the control group,but the difference was not statistically significant (P<0.05); The differences in the levels of CD3+,CD4+,CD8+ and CD4+/ CD8+ before treatment were no significant between two groups (P>0.05); After treatment,the levels of CD3+,CD4+,CD8+ in both groups were significantly lower than before treatment (P<0.05).However,the CD3+ and CD4+ levels and CD4+/ CD8+ values of the observation group were significantly higher than that of the control group (P<0.05),and CD8+ levels were significantly lower than in control group (P<0.05).Conclusion:Oral administration of Fuzheng Guben Decoction can significantly improve the short-term clinical efficacy of concurrent chemoradiation in patients with locally advanced cervical cancer,reduce the adverse reaction,and enhance the patients' immune function.

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