To investigate the effects of Jiawei Xiaoyao Decoction combined with olanzapine on cognitive function,endocrine hormone and nerve function in patients with schizophrenia.Methods:A total of 94 schizophrenic patients admitted to our hospital from June 2015 to June 2017 were selected and divided into observation group(47 cases)and control group(47 cases)according to random number table method.The control group was treated with olanzapine,and the observation group was treated with Jiawei Xiaoyao Decoction on the basis of the control group.The 2 groups were treated for 8 weeks.The curative effects of the 2 groups were compared,and the changes of PANSS score,LOTCA score,endocrine hormone level and nerve function level before and after treatment,and the occurrence of adverse reactions were compared.Results:The total effective rate of the observation group(91.49%)was higher than that of the control group(70.21%)(P<0.05).The PANSS scores of the 2 groups decreased after treatment,while the LOTCA scores increased(observation group:t=45.555,18.928,control group:t=16.472,11.048,P<0.05).After treatment,the PANSS score of the observation group was lower than that of the control group,while the LOTCA score was higher than that of the control group(t=18.893,8.331,P<0.05).After treatment,the levels of TEST,FT3 and FT4 decreased in 2 groups(observation group:t=5.987,6.464,4.352,control group:t=12.492,14.307,7.998,P<0.05).After treatment,the levels of TEST,FT3 and FT4 in observation group were higher than that of control group(t=8.939,12.469,6.014,P<0.05).The serum BDNF levels of 2 groups were increased and NSE levels were decreased after treatment(observation group:t=9.022,13.400,control group:t=5.725,5.626,P<0.05); after treatment,serum BDNF levels in observation group were higher than that of control group,and NSE levels were lower than control group(t=4.089,9.274,P<0.05).The incidence of adverse reaction in observation group(8.51%)was lower than that of control group(29.79%)(P<0.05).Conclusion:Jiawei Xiaoyao Decoction combined with olanzapine can improve the cognitive function of schizophrenic patients.It will not cause serious endocrine hormones and nerve function disorders.It has little adverse reaction,but with good safety.It is worth promotion and research. |