| 引用本文:郭启发，李光，杜敏，卢仲琳.注射用骨瓜提取物治疗四肢骨折对患者创伤指标与凝血功能的影响[J].世界中医药,2018,(10):. |
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| 注射用骨瓜提取物治疗四肢骨折对患者创伤指标与凝血功能的影响 |
| Observation on Effects of Cucumis melo L Extract Injection on Trauma Indexes D-D,CK,CKMB,GPT and Coagulant Function PT,APTT,TT,FIB in Patients with Limb Fracture |
| 投稿时间：2018-05-31 |
| DOI：10.3969/j.issn.1673-7202.2018.10.019 |
| 中文关键词: 注射用骨瓜提取物 四肢骨折 创伤指标 D-D CK CKMB GPT 凝血功能 |
| English Keywords:Cucumis melo L extract injection Limb fracture trauma index D-D CK CKMB GP Coagulant function |
| 基金项目:青海大学附属医院科学创新基金项目(FYXC-2017-03) |
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| 中文摘要: |
| 目的:探讨注射用骨瓜提取物应用于四肢骨折,在凝血功能和创伤指标方面的影响。方法:选取2016年5月至2017年5月青海大学附属医院收治的四肢骨折患者172例,按照随机数字表法随机分为对照组(n=85)和观察组(n=87),全部患者均进行传统复位外固定,对照组使用芪骨胶囊治疗方案,观察组使用注射用骨瓜提取物治疗。观察2组创伤指标、凝血功能指标、功能独立性评定(FIM)在治疗前后的波动,记录不良反应率。结果:1)观察组用药后创伤指标CK(43.62±3.45)U/L、LDH(232.42±11.05) mmol/L、CKMB(26.10±2.41)U/L、GOT(31.19±2.89)U/L、GPT(28.27±3.19)U/L、D-D(177.52±12.56)μg/L均显著低于对照组(P<0.05);2)观察组FIB(3.42±0.34)g/L、PLT(171.19±14.74)×109/L、PT(33.81±3.10)s明显比对照组高,APTT(32.52±2.56)s、TT(15.27±2.47)s比对照组低(P<0.05);3)观察组用药后FIM评分(111.84±5.19)分显著高于对照组(98.35±4.67)分(P<0.05);4)观察组用药后总不良反应率(3.45%)与对照组(8.24%)差异无统计学意义(P>0.05)。结论:对于四肢骨折患者,采取注射用骨瓜提取物进行骨折愈合治疗,可有效改善患者凝血功能的恢复,促进创伤愈合。 |
| English Summary: |
| To investigate the effects of Cucumis melo L extract injection on coagulation function and trauma index of limb fracture.Methods:From May 2016 to May 2017,a total of 172 patients with limb fractures treated in Affiliated Hospital of Qinghai University were selected and randomly divided into control group (n＝85) and observation group (n＝87) according to the random number table method.All subjects underwent conventional external fixation and external fixation.The control group was treated with Qigu capsule and the observation group was treated with Cucumis melo L extract injection.The changes of trauma index,coagulation function index and functional independence assessment (FIM) before and after treatment were observed,and the side effects were recorded.Results:After the treatment,the trauma index such as CK (43.62±3.45) U/L,LDH (232.42±11.05) mmol/L,CKMB (26.10±2.41) U/L,GOT (31.19±2.89) U/L,GPT (28.27±3.19) U/L,D-D (177.52±12.56) μg/L in observation group were decreased more significant than those of the control group (P<0.05).In observation group,the FIB (3.42±0.34) g/L,PLT (171.19±14.74)×109/L,PT (33.81±3.10) s were increased more significantly than those of the control group,APTT (32.52±2.56) s,TT (15.27±2.47) s were decreased significantly than those of the control group (P<0.05).In observation group,after the treatment,the FIM (111.84±5.19) score was significant higher than the control group (98.35±4.67) (P<0.05).After the treatment,there was no significant difference in total side effect rate between the observation group (3.45%) and the control group (8.24%) (P>0.05).Conclusion:For the patients with limb fracture,Cucumis melo L extract injection can effectively improve the recovery of coagulation function and promote wound healing. |
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