To investigate the effects of Pudilan oral liquid combined with azithromycin on serum inflammatory factors and immune functions in the treatment of children with mycoplasma pneumonia.Methods:A total of 115 cases of mycoplasma pneumonia admitted in our hospital from June 2015 to December 2016 were randomly divided into observation group of 58 cases and control group of 57 cases according to the random number table.The control group was treated with azithromycin, and children in the observation group were added Pudilan oral liquid.The clinical curative effect, time of clinical symptoms disappeared, changes of serum inflammatory factors indexes, and the changes of T lymphocyte subsets were observed.Results:The clinical curative effect of the observation group was better than that of the control group (P<0.05).The disappearance time of fever, cough and pulmonary rale in the observation group was significantly lower than that in the control group (P<0.05).After treatment, the serum levels of IL-6, IL-8, TNF-α, RCP and PCT in the observation group were significantly lower (P<0.05), and the degree of reduction in the observation group was significantly better than that in the control group (P<0.05).After treatment, the number of CD3+, CD4+ and CD4+/CD8+ cells in the observation group was significantly higher than that in the control group (P<0.05), while the number of CD8+ cells was significantly lower than that of the control group (P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05).Conclusion:Pudilan oral liquid combined with azithromycin treatment has significant clinical efficacy in children with mycoplasma pneumonia, and can effectively reduce inflammation, improve the immune function of patients, which is worthy of clinical application.