| 引用本文:陈云1，胡立杰2，王婷婷1.蒲地蓝口服液联合阿奇霉素治疗对支原体肺炎患儿血清炎性因子及免疫功能的影响[J].世界中医药,2018,(10):. |
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| 蒲地蓝口服液联合阿奇霉素治疗对支原体肺炎患儿血清炎性因子及免疫功能的影响 |
| Analysis of the Effects of Pudilan Oral Liquid Combined with Azithromycin on Serum Inflammatory Factors and Immune Function in Treatment of Children with Mycoplasma Pneumonia |
| 投稿时间：2017-07-16 |
| DOI：10.3969/j.issn.1673-7202.2018.10.020 |
| 中文关键词: 蒲地蓝口服液 阿奇霉素 支原体肺炎 炎性因子 免疫功能 患儿 C反应蛋白 降钙素原 |
| English Keywords:Pudilan oral liquid Azithromycin Mycoplasma pneumonia Inflammatory factor Immune function Children CRP PCT |
| 基金项目:衡水市重点研发计划项目（2017014015Z） |
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| 中文摘要: |
| 目的：探讨蒲地蓝口服液联合阿奇霉素对支原体肺炎患儿血清炎性因子及免疫功能的影响。方法：选取2015年6月至2016年12月衡水市第四人民医院收治的支原体肺炎患儿115例，按照随机数字表法将患儿随机分为观察组（58例）、对照组（57例），对照组儿童采用阿奇霉素治疗，观察组儿童在阿奇霉素治疗基础上联合使用蒲地蓝口服液治疗，比较2组临床疗效、临床症状消失时间、血清炎性因子变化以及T淋巴细胞亚群变化。结果：观察组儿童临床疗效显著优于对照组（P<0.05）；观察组患儿发热、咳嗽以及罗音消失时间均显著低于对照组（P<0.05）；治疗后观察组患儿血清白细胞介素-6（IL-6）、白细胞介素-8（IL-8）以及肿瘤坏死因子-α、C反应蛋白（RCP）以及降钙素原（PCT）均显著降低（P<0.05），且观察组患儿降低程度优于对照组（P<0.05）；治疗后观察组患儿CD3+、CD4+、CD4+/CD8+细胞数显著高于对照组（P<0.05），而CD8+细胞数显著低于对照组（P<0.05）；2组患儿不良反应发生率差异无统计学意义（P>0.05）。结论：蒲地蓝口服液联合阿奇霉素治疗支原体肺炎患儿具有显著的临床疗效，可有效降低机体炎性反应，改善患儿免疫功能。 |
| English Summary: |
| To investigate the effects of Pudilan oral liquid combined with azithromycin on serum inflammatory factors and immune functions in the treatment of children with mycoplasma pneumonia.Methods:A total of 115 cases of mycoplasma pneumonia admitted in our hospital from June 2015 to December 2016 were randomly divided into observation group of 58 cases and control group of 57 cases according to the random number table.The control group was treated with azithromycin, and children in the observation group were added Pudilan oral liquid.The clinical curative effect, time of clinical symptoms disappeared, changes of serum inflammatory factors indexes, and the changes of T lymphocyte subsets were observed.Results:The clinical curative effect of the observation group was better than that of the control group (P<0.05).The disappearance time of fever, cough and pulmonary rale in the observation group was significantly lower than that in the control group (P<0.05).After treatment, the serum levels of IL-6, IL-8, TNF-α, RCP and PCT in the observation group were significantly lower (P<0.05), and the degree of reduction in the observation group was significantly better than that in the control group (P<0.05).After treatment, the number of CD3+, CD4+ and CD4+/CD8+ cells in the observation group was significantly higher than that in the control group (P<0.05), while the number of CD8+ cells was significantly lower than that of the control group (P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05).Conclusion:Pudilan oral liquid combined with azithromycin treatment has significant clinical efficacy in children with mycoplasma pneumonia, and can effectively reduce inflammation, improve the immune function of patients, which is worthy of clinical application. |
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