| 引用本文:热比姑丽·伊斯拉木1,2，美热古丽·热合曼3，艾西木江·热甫开提1,2，买合苏提·卡德尔1,2，阿不都吉力力·阿布都艾尼1,2.维吾尔医综合治疗银屑病患者的血清差异性代谢组分[J].世界中医药,2018,(10):. |
|
| 维吾尔医综合治疗银屑病患者的血清差异性代谢组分 |
| Analysis of Serum Differential Metabolic Components in Uyghur Medical Treatment in Patients with Psoriasis |
| 投稿时间：2017-06-27 |
| DOI：10.3969/j.issn.1673-7202.2018.10.023 |
| 中文关键词: 银屑病 患者 健康志愿者 血清 代谢组学 维吾尔医 综合治疗 1H-NMR技术 代谢综合征 |
| English Keywords:Psoriatic patient Healthy volunteers Serum Metabolites Uyghur medicine Combined treatment 1H-NMR Technique Metabolic Syndrome |
| 基金项目:新疆维吾尔自治区卫生计生委青年科技人才专项科研项目(2015Y40)，新疆维吾尔自治区中医民族医药科技人才培养计划项目(2016-03-04） |
|
| 摘要点击次数: 1090 |
| 全文下载次数: 1064 |
| 中文摘要: |
| 目的：分析维吾尔医综合治疗银屑病患者的血清差异性代谢组分。方法：选取2014年4月至2015年10月维吾尔医综合治疗的银屑病患者和通过体检确定健康志愿者血清，利用1H-NMR技术结合正交偏最小二乘法，分析检测健康志愿者、银屑病患者血清差异性代谢组分。结果：与健康志愿者比较，银屑病患者血清极低密度脂蛋白（VLDL）、低密度脂蛋白（LDL）、不饱和脂类、糖蛋白、酪氨酸、组氨酸及丙酮含量降低，乳酸、肌酸、甲酸、乙酸及苯丙氨酸水平升高，且差异有统计学意义（P<0.05）。结论：通过维吾尔医综合治疗，银屑病患者血清仍存在氨基酸、脂类及其一些小分子化合代谢紊乱。 |
| English Summary: |
| To analyze serum differential metabolic components in Uyghur medical treatment in patients with psoriasis. Methods:The serum of psoriasis patients and healthy volunteers from Hospital of Xinjiang Traditional Uyghur Medicine from April 2014 to October 2015 were selected. The differential metabolic components of serum from healthy volunteers and patients with psoriasis were analyzed by 1H-NMR technique combined with orthogonal partial least squares method. Results:Compared with healthy volunteers group, VLDL, LDL, unsaturated lipid, glycoprotein, tyrosine, histidine, acetone of serum in psoriasis patients group were decreased and serum lactic acid, creatine, formic acid, acetic acid, phenylalanine were increased. The difference was statistically significant (P<0.05). Conclusion:Psoriasis patients still have amino acid, lipid and some small molecules metabolic disorder by combined treatment of Uyghur Medicine. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
|
|
|
