| 引用本文:朱元，陆海芬，吴明华，王欣彤.通脑饮治疗血管性痴呆疗效观察及其对血清代谢产物的影响[J].世界中医药,2018,(10):. |
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| 通脑饮治疗血管性痴呆疗效观察及其对血清代谢产物的影响 |
| Clinical Efficacy Observation and Effects on Serum Metabolites of Tongnao Decoction in Treating Vascular Dementia |
| 投稿时间：2018-05-10 |
| DOI：10.3969/j.issn.1673-7202.2018.10.024 |
| 中文关键词: 通脑饮 血管性痴呆 血清 糖代谢 脂代谢 凋亡 评分 代谢产物 |
| English Keywords:Tongnao Decoction Vascular dementia Serum Carbohydrate metabolism Lipid metabolism Apoptosis Score Metabolites |
| 基金项目:江苏省卫生厅科研项目(P201620);江苏省“333工程”第二层次培养项目(BRA2016507) |
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| 中文摘要: |
| 目的:探讨通脑饮治疗血管性痴呆的疗效及其对血清代谢产物的影响。方法:选取2015年1月至2017年1月江苏省中医院收治的脑梗死后血管性痴呆患者80例,按照随机数字表法随机分为对照组和观察组,每组40例。2组患者均口服脑复康,观察组加服通脑饮,连续服用8周。2组均于治疗前后检测血黏度、红细胞压积,进行医症候积分、神经功能缺损评分、简易智力状态速查表(MMSE)评分、日常生活能力量表(ADL)评分、长谷痴呆量表(HDS)评分,检测血清中sFas、sFasL、总胆固醇(TC)、三酰甘油(TG)、糖化血红蛋白(HbAlc)、空腹血糖(FPG)水平。治疗后评价临床疗效。结果:观察组治疗后120 s全血黏度、血浆黏度、红细胞压积均较治疗前及对照组治疗后均明显降低(P<0.05)。观察组治疗后中医症候积分、神经功能缺损评分、ADL评分均明显低于对照组,MMSE评分、HDS评分均明显高于对照组(P<0.01)。观察组临床总有效率明显高于对照组(90.0% vs 72.5%;P<0.05)。观察组治疗后血清sFas、sFasL、TC、TG、HbAlc、FPG水平明显低于治疗前及对照组治疗后(P<0.05)。结论:通脑饮在血管性痴呆的临床治疗方面,具有改善血液循环、保护脑组织的作用。 |
| English Summary: |
| To explore the clinical efficacy observation and effects on serum metabolites of Tongnao Decoction in treating vascular dementia.Methods:In the period from January 2015 to January 2017,a total of 80 patients with cerebral infarction after cerebral infarction treated in Jiangsu Provincial Hospital of Traditional Chinese Medicine were selected and randomly divided into the observation group and the control group,with 40 cases in each group.Both groups received oral piracetam,and the observation group was additionally given Tongnao Decoction for 8 weeks.The blood viscosity,erythrocyte deposited,medical symptoms integral,neural function defect scale,MMSE score,ADL score,HDS score.And the serum sFas,sFasL,TC,TG,HbAlc,FPG levels in both groups were detected before and after treatment and the clinical efficacy was evaluated after treatment.Results:After treatment,the total blood viscosity,plasma viscosity and erythrocyte pressure were significantly decreased in the observation group,which were decreased more significantly than those of the control group (P<0.05).After treatment,the TCM syndrome score,neurological deficit score and ADL score were all decreased more significantly in the observation group than those in the control group.The MMSE score and HDS score were increased more significantly in the observation group than those in the control group (P<0.01).The total clinical efficiency of the observation group was significantly higher than that of the control group (90.0% vs 72.5%; P<0.05).After treatment,serum sFas,sFasL,TC,TG,HbAlc,and FPG were decreased more significantly in the observation group than before treatment and the control group (P<0.05).Conclusion:Tongnao Decoction has the function of improving blood circulation and protecting brain tissue in the clinical treatment of vascular dementia. |
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