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引用本文:单魁中1，姜子瑜2，黄辉3.中西医结合治疗中晚期非小细胞肺癌患者的疗效及对肿瘤标志物和细胞免疫功能的影响[J].世界中医药,2018,(10):.

中西医结合治疗中晚期非小细胞肺癌患者的疗效及对肿瘤标志物和细胞免疫功能的影响

Clinical Efficacy of Traditional Chinese Medicine Combined with Western Medicine on Patients with Advanced Non-small Cell Lung Cancer and its Effects on Tumor Markers, Cellular Immune Function and Quality of Life

投稿时间：2017-07-30

DOI：10.3969/j.issn.1673-7202.2018.10.026

中文关键词: 中西医中晚期非小细胞肺癌近期疗效癌胚抗原糖类抗原199 神经元特异性烯醇化酶细胞免疫功能生命质量

English Keywords:Chinese and Western medicine Advanced non-small cell lung cancer Short-term efficacy Carcinoembryonic antigen CA199 Neuron specific enolase Cellular immune function Quality of life

基金项目:江苏省科技项目（BK20151045）

作者	单位
单魁中1，姜子瑜2，黄辉3	1 昆山市第二人民医院肿瘤内科，昆山，215300； 2 江苏省中医药研究院肿瘤内科，南京，210028； 3 昆山市中医医院呼吸内科，昆山，215300

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中文摘要:

目的：探讨中西医结合治疗中晚期非小细胞肺癌患者近期疗效及对患者肿瘤标志物、细胞免疫功能和生命质量的影响。方法：选取2013年12月至2016年12月昆山市第二人民医院收治的中晚期非小细胞肺癌患者94例，按照随机表法分为观察组与对照组，每组47例。观察组采用中西医结合治疗，对照组仅采用GP化疗方案治疗。2组均以21 d为1疗程，连续3个疗程后评价疗效。比较2组近期疗效，治疗前后血清肿瘤标志物和细胞免疫功能变化，生命质量改善和不良反应情况。结果：观察组近期总有效率（63.83%）高于对照组（40.43%）（P<0.05）。2组治疗后癌胚抗原(CEA)、糖类抗原199（CA199）和神经元特异性烯醇化酶(NSE)水平降低（P<0.05）；观察组治疗后CEA、CA199和NSE水平低于对照组（P<0.05）。观察组治疗后CD3+、CD4+和CD4+/CD8+增加（P<0.05），而对照组治疗后CD3+、CD4+和CD4+/CD8+降低（P<0.05）；观察组治疗后CD3+、CD4+和CD4+/CD8+高于对照组（P<0.05）。观察组生命质量提高率（59.57%）高于对照组（36.17%）（P<0.05）。观察组胃肠道反应、白细胞减少、血小板减少及乏力发生率低于对照组（P<0.05）。结论：中西医结合治疗中晚期非小细胞肺癌患者近期疗效明显，且可改善患者血清肿瘤标志物和细胞免疫功能，提高患者生命质量，降低不良反应，具有重要研究价值。

English Summary:

To investigate the short-term effect of combined treatment of traditional Chinese and Western Medicine on patients with advanced non-small cell lung cancer (NSCLC) and its effects on tumor markers, cellular immune function and quality of life.Methods:A total of 94 cases of advanced NSCLC in our hospital from December 2013 to December 2016 were randomly divided into the observation group (47 cases) and the control group (47 cases).The observation group was treated with combination of traditional Chinese medicine and Western medicine, while the control group was treated with GP chemotherapy only.The two groups were treated for 21 d as 1 course, and the curative effect was evaluated after 3 consecutive courses.The short-term effects of the two groups were compared.The changes of serum tumor markers and cellular immune function, the improvement of life quality and the toxic and side effects were observed before and after treatment.Results:The total effective rate in the observation group (63.83%) was higher than that in the control group (40.43%) (P<0.05).CEA, CA199 and NSE decreased after treatment in two groups (observation group:t=16.6497, 22.7240, 16.0180, the control group:t=8.0496, 11.6747, 7.2696, P<0.05); the observation group after treatment, CEA, CA199 and NSE were lower than the control group (t=8.9416, 14.4451, 8.5756, P<0.05).The observation group after treatment, CD3+, CD4+ and CD4+/CD8+ increased (t=11.0410, 7.4541, 7.9279, P<0.05), while the control group after treatment, CD3+, CD4+ and CD4+/CD8+ decreased (t=7.6467, 5.4521, 5.2735, P<0.05); the observation group after treatment CD3+, CD4+ and CD4+/CD8+ was higher than the control group (t=18.3227, 12.0990, 12.1224, P<0.05).The improvement rate of quality of life in observation group (59.57%) was higher than that in control group (36.17%) (P<0.05).The incidence of gastrointestinal reaction, leukocyte reduction, thrombocytopenia and fatigue in the observation group was lower than that in the control group (P<0.05).Conclusion:Combined traditional Chinese and Western medicine in the treatment of advanced NSCLC and can improve the serum tumor markers and cell immune function, improve the quality of life of patients, reduce the adverse reaction, with important research value.

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