| 引用本文:朱先州1，王静敏2.芍药甘草汤联合尼莫地平治疗糖尿病下肢周围神经病变的临床疗效及对神经电生理特征的影响[J].世界中医药,2018,(10):. |
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| 芍药甘草汤联合尼莫地平治疗糖尿病下肢周围神经病变的临床疗效及对神经电生理特征的影响 |
| Clinical Observation and Electrophysiological Characteristics of Shaoyao Gancao Decoction Combined with Nimodipine in Treatment of Diabetic Peripheral Neuropathy |
| 投稿时间：2017-07-31 |
| DOI：10.3969/j.issn.1673-7202.2018.10.030 |
| 中文关键词: 芍药甘草汤；糖尿病；下肢周围神经病变；踝臂指数；临床疗效；神经电生理 交感皮肤反应 神经传导速度 |
| English Keywords:Shaoyaogancao decoction Diabetes Peripheral neuropathy ABI Clinical efficacy Electrophysiology SSR NCV |
| 基金项目:鹤壁市科技局科研立项(2015-J-11) |
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| 中文摘要: |
| 目的：观察芍药甘草汤联合尼莫地平治疗糖尿病下肢周围神经病变的临床疗效，并探讨其对糖尿病下肢周围病变神经电生理特征的影响。方法：选取2009年4月至2015年11月鹤壁市人民医院收治的2型糖尿病下肢周围神经病变患者120例，采用随机数字表法分为观察组和对照组，同时选取同期住院的2型糖尿病未合并下肢周围神经病变患者60例纳入糖尿病组。糖尿病组行糖尿病基础治疗，对照组在糖尿病组的基础上予以尼莫地平，观察组在对照组基础上行芍药甘草汤治疗。记录空腹血糖(FBG)、餐后2 h血糖(2 hPBG)、糖化血红蛋白（HbAlc），评估踝臂指数（ABI）以及由专业医师进行神经电生理检测。结果：治疗后FBG、2 hPBG、HbAlc均差异有统计学意义（P<0.05）；其中观察组FBG、2 hPBG和HbAlc的表达水平均较对照组和糖尿病组低（P<0.05）。治疗后ABI观察组和对照组较治疗前升高（P<0.05），且观察组升高程度优于对照组（P<0.05）和糖尿病组（P<0.05）治疗后交感皮肤反应（SSR）的潜伏期和波幅中观察组和对照组均较治疗前下降（P<0.05），且观察组下降程度优于对照组（P<0.05）和糖尿病组（P<0.05）。治疗前观察组和对照组神经传导速度（NCV）均较糖尿病组低（P<0.05），治疗后观察组和对照组中NCV均见增加（P<0.05），观察组优于对照组（P<0.05）。结论：芍药甘草汤联合尼莫地平治疗糖尿病下肢周围病变有效改善其血糖水平和ABI等下肢功能，同时改善其SSR和NCV等神经电生理特征，具有一定的临床参考价值。 |
| English Summary: |
| To observe the clinical efficacy of Shaoyao Gancao decoction combined with nimodipine in the treatment of diabetic peripheral neuropathy, and to investigate the effects on electrophysiological characteristics of diabetic peripheral neuropathy.Methods:A total of 120 cases of lower extremity in patients with type 2 diabetes peripheral neuropathy hospitalized in our hospital from April 2009 to November 2015 were randomly divided into observation group and control group.And 60 cases of type 2 diabetes hospitalized patients without peripheral neuropathy with lower extremity were included in the diabetic group.The diabetic group received the basic treatment of diabetes, and the control group was given nimodipine on the basis of the diabetic group.The observation group was treated with Shaoyao Gancao decoction on the basis of the control group.Fasting plasma glucose (FBG), postprandial 2H blood glucose (2 hPBG), glycosylated hemoglobin (HbAlc), ankle brachial index (ABI), and electrophysiological examination by professional physicians were recorded.Results:1) After treatment, FBG, 2 hPBG and HbAlc were significantly different (P<0.05), in which the expression levels of FBG, 2 hPBG and HbAlc in the observation group were lower than those in the control group and diabetes group (P<0.05).2) After treatment, the ABI observation group and the control group were higher than before treatment (P<0.05), and the observation group was superior to the control group (P<0.05) and the diabetes group (P<0.05).3) After treatment, the latency and amplitude of SSR decreased in the observation group and the control group (P<0.05), and the decrease in the observation group was better than that in the control group (P<0.05) and the diabetes group (P<0.05).4) Before treatment, the NCV in the observation group and the control group were lower than that in the diabetic group (P<0.05).After treatment, the NCV in the observation group and the control group increased (P<0.05), and the observation group was better than the control group (P<0.05).Conclusion:Shaoyao Gancao decoction combined with nimodipine in the treatment of diabetic lower extremity peripheral lesions can improve the blood glucose level of ABI and lower limb function, while improving its SSR and NCV nerve electrophysiological characteristics, with certain clinical reference value. |
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