| 引用本文:李宏贵1，徐嘉辉2，朱婉雯3，余德钊2.苏神方治疗小儿幽门螺旋杆菌相关性胃炎的疗效观察[J].世界中医药,2018,(10):. |
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| 苏神方治疗小儿幽门螺旋杆菌相关性胃炎的疗效观察 |
| Effect of Sushen Decoration in Treating the Helicobator Pylori Related Gastritis in Children |
| 投稿时间：2018-01-25 |
| DOI：10.3969/j.issn.1673-7202.2018.10.039 |
| 中文关键词: 幽门螺旋杆菌 胃炎 苏神方 白细胞介素 疗效 作用机制 中医药 小儿 |
| English Keywords:Helicobator pylori Gastritis Sushen decoration Interleukin Clinical effect Mechanism Traditional Chinese medicine Children |
| 基金项目:广东省中医药管理局科研项目(20171018) |
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| 中文摘要: |
| 目的:观察苏神方治疗幽门螺旋杆菌(HP)相关性胃炎的临床疗效。方法:选取2016年3月至2017年3月广东省第二中医院与广州中医药大学第一附属医院儿科收治的符合HP相关性胃炎患儿100例作为研究对象。按照随机数字表随机分为观察组和对照组,每组50例。对照组予阿莫西林、克拉霉素及奥美拉唑三联治疗,观察组在对照组的基础上,予苏神方治疗。2组均治疗21 d。观察2组患儿治疗前后的临床症状改善情况,采用中医证候评分进行总体评价。检测2组患儿血清白细胞介素IL-6、IL-10的水平。停药后3个月随访,观察2组患儿HP转阴率与症状复发率。结果:观察组患儿总有效率为96.00%,对照组患儿总有效率为82.00%,2组总有效率比较,差异有统计学意义(P<0.05)。观察组患儿胃脘疼痛、上腹不适、恶心呕吐、饥不欲食症状评分均低于对照组,差异有统计学意义(P<0.05)。观察组患者治疗后血清IL-6低于对照组,差异有统计学意义,且观察组治疗前后IL-6差值高于对照组,差异有统计学意义(P<0.05)。但是,2组患儿治疗后血清IL-10含量比较,差异无统计学意义(P>0.05),且2组患儿治疗前后IL-10差值相当,差异无统计学意义(P>0.05)。随访3个月,观察组患儿HP转阴率为92.00%(46/50),对照组则为74.00%(37/50),2组HP转阴率比较,差异有统计学意义(P<0.05)。此外,观察组患儿复发率为6.00%(3/50),对照组患儿则为24.00%(12/50),2组复发率比较,差异有统计学意义(P<0.05)。结论:苏神方能够有效改善HP相关性胃炎患儿的临床症状,抑制HP作用显著,且能显著减少复发率,其作用与减少IL-6的表达有关。 |
| English Summary: |
| To investigate the effect of Sushen decoration in treating the pediatric Helicobator pylori(HP) related gastritis.Methods:A total of 100 patients with HP related gastritis from the pediatric departments of Guangdong No.2 TCM hospital and first affiliated hospital of Guangzhou University of TCM during March 2016 to March 2017 were divided in to observation and control group by random number table,and there were 50 patients in each.Patients in control one were treated with amoxicillin,clarithromycin and omeprazole.However,patients in observation group were additionally given the Sushen decoration.And all patients were treated with 21 days.The improvement of manifestations in each group was observed and the total effect before and after the medication was evaluated by the TCM symptom scores.The serum concentrations of interleukin ( IL )-6 and IL-10 were tested.3 months after the medication withdrawal,the negative conversion rate of HP and the recurrence rate of the symptoms were collected as well.Results:The total effective rate of observation group was 96.00% while the total effective rate in control one was 82.00% and there was the difference ( P<0.05 ).The TCM symptom scores of stomach pain,epigastric discomfort,nausea and vomiting and hunger without desire to eat in the observation were obviously less than the control group,and there were the differences ( P<0.05 ).Moreover,the serum concentration of IL-6 was less than the control one while the differences of IL-6 before and after the treatment in the observation group was more than the control group,and there were the differences ( P<0.05 ).Nevertheless,there were no differences in each group on the concentration and its differences of IL-10 ( P>0.05 ).In addition,3 months after the medication withdrawal,the negative conversion rate of HP in the observation group was 92.00%（46/50） while it was 74.00%（37/50） in the control one and there was the difference（P<0.05）.Conclusion:Sushen decoration could improve the manifestations of HP related gastritis which could inhibit the recurrent rate with bacteriostasis and its effect was relevant to decrease the impression of IL-6. |
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