世界中医药
文章摘要
引用本文:郭华1,王旭玲2.葛根素对糖尿病合并颈动脉硬化患者氧化应激和血液流变学的影响[J].世界中医药,2018,(10):.  
葛根素对糖尿病合并颈动脉硬化患者氧化应激和血液流变学的影响
Effects of Puerarin on Oxidative Stress and Hemorheology of Patients with Diabetes Mellitus Combined with Carotid Atherosclerosis
投稿时间:2018-07-07  
DOI:10.3969/j.issn.1673-7202.2018.10.040
中文关键词:  糖尿病  颈动脉硬化  葛根素  氧化应激  血液流变学
English Keywords:Diabetes mellitus  Carotid atherosclerosis  Puerarin  Oxidative stress  Hemorheology
基金项目:哈尔滨科技创新人才(2017RAXQJ069)
作者单位
郭华1,王旭玲2 1 北京中医医院顺义医院内分泌科,北京101300 2 黑龙江省中医医院内分泌科哈尔滨150000 
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中文摘要:
      目的:研究葛根素对糖尿病合并颈动脉硬化患者氧化应激和血液流变学的影响。方法:选取2015年10月至2017年2月北京中医医院顺义医院收治的糖尿病合并颈动脉硬化患者114例,随机分为对照组和观察组,每组57例。对照组采用胰岛素及格列本脲治疗,并控制饮食;观察组在对照组基础上加用葛根素治疗,2组均连续治疗1个月。统计2组患者临床疗效;比较2组患者治疗前后氧化应激指标、血管内皮素水平及血液流变学指标。结果:治疗后观察组的总有效率为92.98%,显著高于对照组的84.21%(P<0.05);对照组治疗前后各氧化应激及血流变指标比较,差异无统计学意义(P>0.05),与治疗前比较,治疗后观察组血清超氧化物歧化酶(SOD)、一氧化氮(NO)水平均显著升高,丙二醛(MDA)及血管内皮素-1(ET-1)水平显著下降,2组差异有统计学意义(P<0.05),治疗后观察组患者全血高切、低切黏度,血浆黏度,红细胞聚集指数等均显著下降,且明显低于对照组(P<0.05)。结论:葛根素治疗糖尿病合并颈动脉硬化可有效缓解患者氧化应激异常状态,降低脂质过氧化物MDA水平,同时改善其血液流变学,抑制颈动脉硬化,提高临床疗效。
English Summary:
      To explore the effects of Puerarin on oxidative stress and hemorheology of patients with diabetes mellitus combined with carotid atherosclerosis.Methods:A total of 114 cases of diabetes mellitus combined with carotid atherosclerosis patients in Beijing Hospital Traditional Chinese Medicine Shunyi Hospital from October 2015 to February 2017 were selected and randomly divided into observation group and control group with 57 cases in each group.The control group was treated with insulin and glibenclamide,and the patient's diet was controlled while observation group was treated with puerarin on the basic of control group.And 2 groups were treated for 1 month continuously.The clinical efficacy of 2 groups was recorded by statistic.The oxidative stress indexes,endothelin level and hemorheology in 2 groups before and after treatment were compared.Results:The total effective rate was 92.98% in the observation group,which was significantly higher than 84.21% in the control group (P<0.05),and there was no significant difference in the indexes of oxidative stress and hemorheology before and after treatment in the control group (P>0.05).The result of the comparison with before treatment showed that the levels of serum SOD,NO in observation group after treatment increased significantly,the MDA and ET-1 levels decreased significantly and there were significant differences between 2 groups (P<0.05 or P<0.01).Compared with before treatment,the high blood viscosity,low shear viscosity,plasma viscosity,red cell aggregation index in observation group after treatment decreased significantly,and these data of observation group were significantly lower than the data of control group (P<0.01).Conclusion:Puerarin in the treatment of diabetes mellitus combined with carotid atherosclerosis can significantly relief the oxidative stress abnormal state of patients and reduce the levels of lipid peroxidation product MDA and improve the hemorheology,which will in turn inhibit the carotid atherosclerosis,improve clinical efficacy.
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