| 引用本文:陈丹丹，孙琛，卫培峰.黄连联合葛根用药对大鼠的降血糖作用[J].世界中医药,2018,(10):. |
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| 黄连联合葛根用药对大鼠的降血糖作用 |
| Study on Hypoglycemic Effects of the Combination of Rhizoma Coptidis and Radix Puerariae Lobatae on Rats |
| 投稿时间：2017-08-08 |
| DOI：10.3969/j.issn.1673-7202.2018.10.047 |
| 中文关键词: 黄连联合葛根用药 降血糖作用 黄连 葛根 血糖 胰岛素敏感指数 抗氧化作用 胰岛素抵抗力 |
| English Keywords:Combination of Rhizoma Coptidis and Radix Puerariae Lobatae Hypoglycemic effects Rhizoma Coptidis Radix Puerariae Lobatae Blood sugar value Insulin sensitivity index Anti-oxidation effect Insulin resistance |
| 基金项目:陕西中医药大学校级课题(2015QN25) |
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| 中文摘要: |
| 目的：研究黄连联合葛根用药对高血糖大鼠的降血糖作用。方法：选取SD大鼠，采用链脲佐菌素腹腔注射造模，将造模成功的大鼠(血糖≥11.1 mmol/L)随机分为空白对照组、模型组、二甲双胍组、黄连-葛根大、中、小剂量组，连续给药21 d后，观察黄连-葛根大、中、小剂量组队高血糖大鼠血糖、胰岛素敏感指数、过氧化氢酶(CAT)、谷胱甘肽过氧化物酶(GSH-Px)、超氧化物歧化酶（SOD）、丙二醛（MDA）的影响。结果：黄连-葛根大、中、小剂量可以明显降低高血糖大鼠的血糖值，提高大鼠的胰岛素敏感指数，升高大鼠体内CAT、GSH-Px和SOD活力，降低MDA水平。结论：黄连-葛根大、中、小剂量可以明显降低高血糖大鼠的血糖值，提高小鼠的抗氧化能力，提高大鼠的胰岛素敏感指数并降低胰岛素抵抗力。 |
| English Summary: |
| To study on hypoglycemic effects of the combination of Rhizoma Coptidis and Radix Puerariae Lobatae on rats.Methods:SD rats were selected.Streptozotocin was injected into abdomen for molding.Rat with successful molding(blood sugar ≥ 11.1 mmol/L were randomly divided into the following groups:blank control group，model group,metformin group,Rhizoma Rhizoma Coptidis and Radix Puerariae Lobatae groups of high-dose,middle-dose and low-dose.After giving medicine for 21 days,blood sugar，the insulin sensitivity index，CAT、SOD、GSH-Px and MDA in serum of high blood rats,were observed in Rhizoma Coptidis and Radix Puerariae Lobatae groups of high-dose,middle-dose and low-dose.Results:The high-dose,middle-dose and low-dose of Rhizoma Coptidis and Radix Puerariae Lobatae could apparently reduce blood sugar value of hyperglycemia rats,significantly improved the insulin sensitivity index，significantly increased the vitality of CAT、GSH-Px,SOD in rats and lowered the content of MDA.Conclusion:The high-dose,middle-dose and low-dose of Rhizoma Coptidis and Radix Puerariae Lobatae could apparently reduce blood sugar value of hyperglycemia rats,improve antioxidant ability of rats and reduce insulin sensitivity index of rats. |
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