To investigate the influence of water extract from Guizhou cyclocarya paliurus on the metabolism of blood glucose and blood lipid in type Ⅱ diabetic rats.Methods:The type Ⅱ diabetes mellitus rats model were induced by streptozocin (STZ),and randomly divided these rats into model control,Avandamet (200 mg/kg),blank control,low does (1.5 g/kg),medium does (3 g/kg) and high does (6 g/kg) groups.After 12 weeks oral administration,the test of the fasting blood glucose level was taken every 4 weeks during this period,and the TC,HDL-C,LDL-C,TG,GSP were measured in the last does.The pancreas and liver were removed to assess the pathological morphology by HE staining.Results:The medium does and high does groups could significantly reduce the fasting blood glucose level of the type Ⅱ diabetic rats,induced a significant reduction in TC,TG,LDL-C and GSP levels (P<0.05 or P<0.01),and improve pancreatic and liver histopathological changes.Conclusion:The water extract of Guizhou cyclocarya paliurus has significant hypoglycemic and hypolipidemic effects on type Ⅱ diabetes mellitus rats and can alleviate the pancreas and liver damage.