| 引用本文:陈旺，张礼行，陈小雪，李潇，蓝伦礼，廖玮涛，曾宇.贵州青钱柳对2型糖尿病大鼠血糖及血脂的影响[J].世界中医药,2018,(10):. |
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| 贵州青钱柳对2型糖尿病大鼠血糖及血脂的影响 |
| Study on Effects of Guizhou Cyclocarya Paliurus on Blood Glucose and Blood Lipid Type Ⅱ Diabetic Rats |
| 投稿时间：2017-12-18 |
| DOI：10.3969/j.issn.1673-7202.2018.10.055 |
| 中文关键词: 贵州青钱柳 2型糖尿病 水提液 血糖 血脂 糖化血清蛋白 胰腺 |
| English Keywords:Guizhou Cyclocarya paliurus Type Ⅱ diabetes mellitus Water extract Blood glucose Blood lipid Glycosylated serum protein Pancreas Liver |
| 基金项目:贵州省科技厅-剑河县中药材产业科技合作专项计划项目（剑科合字5号）;国家级大学生创新创业训练计划项目（201510573008）;广东药科大学创新创强项目（2015）;广州市创新创业教育项目（2017114209） |
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| 中文摘要: |
| 目的：研究贵州青钱柳水提液对2型糖尿病大鼠糖脂代谢的影响。方法：选取雄性SD大鼠120只。通过高脂饮食加链脲佐菌素（STZ）诱导2型糖尿病大鼠模型，实验分为6组：STZ模型组、二甲双胍马来酸罗格列酮（200 mg/kg）阳性组、青钱柳水提液低剂量组（1.5 g/kg）、中剂量组（3 g/kg）、高剂量组（6 g/kg），另外设立正常对照组。连续灌胃给药12周，每4周检测空腹血糖，最后用药后检测血清总胆固醇（TC）、三酰甘油（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、糖化血清蛋白（GSP）等指标，对胰腺和肝脏进行苏木精-伊红（HE）染色观察病理形态学。结果：青钱柳水提液中高剂量组2型糖尿病大鼠空腹血糖明显降低，血清中TC、LDL-C、TG、GSP显著降低（P<0.05）,并且胰腺和肝脏组织病理学得到改善。结论：贵州青钱柳水提液对2型糖尿病模型大鼠有明显降血糖及降血脂的作用，并可以减轻其胰腺及肝脏的损伤。 |
| English Summary: |
| To investigate the influence of water extract from Guizhou cyclocarya paliurus on the metabolism of blood glucose and blood lipid in type Ⅱ diabetic rats.Methods:The type Ⅱ diabetes mellitus rats model were induced by streptozocin (STZ),and randomly divided these rats into model control,Avandamet (200 mg/kg),blank control,low does (1.5 g/kg),medium does (3 g/kg) and high does (6 g/kg) groups.After 12 weeks oral administration,the test of the fasting blood glucose level was taken every 4 weeks during this period,and the TC,HDL-C,LDL-C,TG,GSP were measured in the last does.The pancreas and liver were removed to assess the pathological morphology by HE staining.Results:The medium does and high does groups could significantly reduce the fasting blood glucose level of the type Ⅱ diabetic rats,induced a significant reduction in TC,TG,LDL-C and GSP levels (P<0.05 or P<0.01),and improve pancreatic and liver histopathological changes.Conclusion:The water extract of Guizhou cyclocarya paliurus has significant hypoglycemic and hypolipidemic effects on type Ⅱ diabetes mellitus rats and can alleviate the pancreas and liver damage. |
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