To evaluate the effects of integrated Chinese and western medicine in the treatment of neurological autoimmune diseases.Methods:The literature was comprehensively searched in China National Knowledge Infrastructure (CNKI),Chinese Biomedical Literature Database (CBM),Wan Fang Database,Chinese VIP database,PubMed,Cochrane Library,etc.to collect the randomized controlled trials about integrated Chinese and western medicine in the treatment of neurological autoimmune diseases.The time frame was range from January 1,2000 to December 31,2017.The neurological autoimmune diseases mainly occur in the central nervous system and peripheral nerves.Therefore,multiple sclerosis was chosen as the representative of the central nervous system,and Guillain-Barre syndrome was chosen as the representative of the peripheral nervous system.The bias risk and quality of the literature were evaluated.EDSS score (Extended Disability Status Scale),effective rate,clinical symptom score,neurological functional sign score,recurrence frequency,incidence rate of adverse reactions were chosen as the markers of outcome variables of multiple sclerosis,and the effective rate and Hughes score were chosen as the markers of outcome variables of Guillain-Barre syndrome.Results:For multiple sclerosis,a total of 16 randomized controlled trials consisted of 800 cases were included.The results of meta-analysis showed that the data could be extracted from 9 out of 10 studies in which the EDSS score was observed.The data were as follows.MD and 95%CI were-1.07 (-1.79,-0.36),P<0.05,which had difference in statistical analysis.With the effective rate observed in 10 studies,OR and 95%CI were 5.91 (3.51,9.94),P<0.001,which had significant difference in statistical analysis.With the clinical symptom score observed in 4 studies,MD and 95%CI were 0.30,(-3.71,4.31),P=0.88>0.05,which had no significant difference in statistical analysis.With the neurological functional sign score observed in 3 studies,MD and 95%CI were-2.11,(-6.86,2.64),P=0.38>0.05,which had no significant difference in statistical analysis.With the recurrence frequency observed in 3 studies,MD and 95%CI were-0.41,(-0.56,-0.26),P<0.001,which had significant difference in statistical analysis.With the incidence rate of adverse reactions observed in 4 studies,the data could be extracted from 3 ones,OR and 95%CI were 0.20,(0.03,1.42),P>0.05,which had no significant difference in statistical analysis.For Guillain-Barre syndrome,9 randomized controlled clinical trials consisted of 599 cases were eventually included.With effective rate reported in 9 studies,the comparison between the experimental group and the control group showed that the value of OR was 3.38,and the 95% CI was (1.87,6.14),P<0.001,which had significant difference in statistical analysis.With Hughes score observed in 3 studies,MD and 95%CI were-0.41(-0.75,-0.07),P=0.02<0.05,which had difference in statistical analysis.Conclusion:Integrated Chinese and western medicine in the treatment of multiple sclerosis is able to improve its efficiency,reduce the recurrence frequency and improve nerve defect compared with the western medicine treatment only.In the case of Guillain-Barre syndrome,this treatment not only has obvious efficiency,but also improves the physical function of the limbs.It further demonstrates that integrated Chinese and western medicine has significant clinical effects in the treatment of neurological autoimmune diseases.