Professor Li believes that all pathogenic evil spirits have the characteristics of toxic transformation，toxic production，toxic accumulation and toxic brew，and the deterioration of the environment leads to the deficiency of vital energy in the human body.Toxic evil has become the main pathogenic factor in the pathogenesis of skin diseases.Treatment of skin disease with dermatotoxicity theory has become an important clinical therapeutic principle.Detoxification can be widely used in the treatment of skin diseases.