| 引用本文:孙雪松，王吉元，李树斌，陈冬梅.大柴胡汤治疗痰瘀互结型支气管哮喘的临床疗效及其对外周血清白细胞介素-8和肿瘤坏死因子-α的影响[J].世界中医药,2018,(11):. |
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| 大柴胡汤治疗痰瘀互结型支气管哮喘的临床疗效及其对外周血清白细胞介素-8和肿瘤坏死因子-α的影响 |
| Clinical Observation of Dachaihu Decoction in Treating Intermin-Gled Phlegm and Blood Stasis Type of Bronchial Asthma and Effects on TNF-α and IL-8 of Peripheral Serum |
| 投稿时间：2017-12-11 |
| DOI：10.3969/j.issn.1673-7202.2018.11.012 |
| 中文关键词: 支气管哮喘 大柴胡汤 中医药治疗 痰瘀互结 白细胞介素-8 肿瘤坏死因子-α 临床观察 气道重塑 |
| English Keywords:Bronchial asthma Dachaihu Decoction Traditional Chinese medicine treatment Intermin-gled phlegm and blood stasis IL-8 TNF-α Clinical observation Airway remodeling |
| 基金项目:中国中医科学院广安门医院南区院级课题(Y2015-03） |
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| 中文摘要: |
| 目的：观察大柴胡汤治疗痰瘀互结型支气管哮喘的临床疗效。方法：选取2016年1月至2017年3月中国中医科学院广安门医院南区收治的痰瘀互结型支气管哮喘患者80例，采用随机数表法分为2组，每组40例，对照组脱落1例，完成39例，中药组完成40例。其中中药组给予大柴胡汤加味治疗；对照组根据病情分级给予常规西药吸入治疗。观察2组中医症状积分、ACT评分、肺功能变化并观察临床疗效。同时测定2组治疗前后血清TNF-α及IL-8水平。结果：2组经治疗后中医证候积分、哮喘控制测试评分表(ACT)评分、肺功能均得到明显改善。中药组在中医症状积分方面改善更明显。经治疗后患者血清中TNF-α及IL-8水平均有明显下降。结论：应用大柴胡汤加味治疗痰瘀互结型支气管哮喘疗效确切，考虑其作用机制可能与抑制炎性反应有关。 |
| English Summary: |
| To observe clinical effects of Dachaihu Decoction on bronchial asthma with intermin-gled phlegm and blood stasis syndrome.Methods:A total of 80 cases of patients with bronchial asthma with intermin-gled phlegm and blood stasis syndrome in the outpatient and ward department of respiration in our hospital were randomly divided into 2 groups,with 40 cases in each group.1 patient fell off from control group,so 39 cases were finished in control group,and 40 cases in treatment group.The treatment group was treated with Dachaihu Decoction.The control group was given the conventional Western medical treatment according to conditions.The changes of symptom score,ACT score,pulmonary function,and clinical efficacy were observed.Serum TNF-α and IL-8 concentrations were measured before and after treatment in 2 groups.Results:After treatment,both groups had marked improvements on symptom scores,ACT scores and pulmonary function.Treatment group had more pronounced effects on symptom scores.After treatment,the serum levels of TNF-α and IL-8 in patients were significantly decreased.Conclusion:It is confirmed that Dachaihu Decoction on the treatment asthma is efficacious.The mechanism may be related to the inhibition of inflammatory reaction. |
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