| 引用本文:赫伟丽1，苑晓晨2，赵帆1，徐光福1，张爱军1.益气解毒通络颗粒对乙肝肝硬化患者肝星状细胞标记物VEGF和PDGF-AB的影响[J].世界中医药,2018,(11):. |
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| 益气解毒通络颗粒对乙肝肝硬化患者肝星状细胞标记物VEGF和PDGF-AB的影响 |
| Effects of Yiqi Jiedu Tongluo Granules on VEGF and PDGF-AB in Patients with Post-Hepatitis B Liver Cirrhosis |
| 投稿时间：2018-05-04 |
| DOI：10.3969/j.issn.1673-7202.2018.11.013 |
| 中文关键词: 益气解毒通络颗粒 乙肝肝硬化 毒损肝络,气虚络闭型 益气解毒通络法 肝星状细胞 血管内皮生长因子 血小板衍生生长因子 血小板衍生生长因子-AB |
| English Keywords:Yiqi Jiedu Tongluo Granules Post-hepatitis B liver cirrhosis Toxic damage to the liver collaterals Qi deficiency collateral closure Yiqi Jiedu Tongluo Granules method Hepatic stellate cell VEGF PDGF PDGF-AB |
| 基金项目:2015年北京中医药校级课题(2015-JYB-JSMS085) |
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| 中文摘要: |
| 目的:探讨益气解毒通络颗粒剂治疗乙肝肝硬化好转的分子机制,完善该方治疗乙肝肝硬化的理论基础。方法:选取2015年6月至2017年10月在北京中医药大学东直门医院,采用简单随机化分组方法,随机选择符合入排标准的体检中心体检健康者15例,肝炎门诊就诊的乙肝肝硬化患者42例。乙肝肝硬化患者均已规范使用抗病毒药恩替卡韦分散片治疗,入组后予益气解毒通络颗粒治疗6个月;对健康者,乙肝肝硬化患者治疗前、治疗6个月后,分别采集血样,待标本集中后采用酶联免疫吸附法成批检测VEGF、PDGF-AB含量。并将测定结果进行统计分析。结果:结果显示,血清VEGF水平乙肝肝硬化患者治疗前较健康者轻度升高,治疗后较治疗前及健康者均有所下降,但组间比较无统计学意义(P>0.05);血清PDGF-AB水平乙肝肝硬化患者治疗前较健康者显著降低(P<0.001),治疗后较治疗前有所升高(P<0.05)但仍低于健康者(P<0.05)。结论:VEGF和PDGF-AB水平的变化与乙肝后肝硬化的发病相关,益气解毒通络颗粒能够改善乙肝肝硬化患者血清VEGF和PDGF-AB水平,这可能是其治疗乙肝肝硬化的作用机制之一。 |
| English Summary: |
| To discuss the molecular mechanism of Yiqi Jiedu Tongluo Granules，which was used for treating patients with post-hepatitis B liver cirrhosis，and to provide the theory foundation for it.Methods:Cases were randomly selected from the visitors in Dongzhimen Hospital from June 2015 to October 2017 with 15 healthy persons of Medical Examination Center，and 42 patients with post-hepatitis B liver cirrhosis of Hepatitis clinic.The patients with post-hepatitis B liver cirrhosis had been treated by entecavir.The patients were treated with Yiqi Jiedu Tongluo Granules for 6 months; The serum of the healthy persons，the patients before treatment，and the patients after treatment was collected.The method of ELISA was used to detect the serum level of VEGF and PDGF-AB.Results:The serum level of VEGF in patients with post-hepatitis B liver cirrhosis was increased than those of healthy persons，and after-treating was decreased than before-treating.But the level of VEGF was not statistically significant among groups (P>0.05).The serum level of PDGF-AB in patients with post-hepatitis B liver cirrhosis was significantly decreased than those of healthy persons (P<0.001); after-treating was increased than before-treating (P<0.05)，but was lower than those of healthy persons (P<0.05).Conclusion:The serum level of VEGF and PDGF-AB has some relativity with post-hepatitis B liver cirrhosis.Yiqi Jiedu Tongluo Granules can affect the serum level of VEGF and PDGF-AB，which may be one of its treatment mechanisms. |
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