| 引用本文:刘永娟，王福琴，李成伟，肖辉，戚明.益气养心方联合丹参注射液治疗慢性阻塞性肺疾病合并肺心病患者的临床疗效[J].世界中医药,2018,(11):. |
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| 益气养心方联合丹参注射液治疗慢性阻塞性肺疾病合并肺心病患者的临床疗效 |
| Clinical Efficiency Observation of Yiqi Yangxin Formula with Danshen Injections in Treating Chronic Obstructive Pulmonary Disease and Pneumocardial Disease |
| 投稿时间：2017-12-07 |
| DOI：10.3969/j.issn.1673-7202.2018.11.014 |
| 中文关键词: 益气养心方 丹参注射液 慢性阻塞性肺疾病 肺心病 血气指标 纤溶指标 肺功能 不良反应 |
| English Keywords:Yiqi Yangxin Formula Danshen injection Chronic obstructive pulmonary disease(COPD) Pneumocardial disease Blood gas index Fibrinolysis index Pulmonary function Adverse reactions |
| 基金项目:山东省中医药科技发展计划项目（2017-482） |
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| 中文摘要: |
| 目的：探讨益气养心方联合丹参注射液治疗慢性阻塞性肺疾病（COPD）合并肺心病患者的临床疗效。方法:选取2015年9月至2016年7月德州市中医院西院区收治的COPD合并肺心病患者68例进行回顾性分析，依照就诊先后将68例患者随机分为观察组和对照组，每组34例。对照组患者在常规治疗基础上联用脉络宁注射液静脉点注，观察组患者在常规治疗基础上加用益气养心方联合丹参注射液治疗，比较2组患者最终疗效及治疗前后肺功能、血气指标、血凝及纤溶改善情况。结果：2组患者治疗有效率比较，观察组显著高于对照组（P<0.05）；疗程结束后，2组第1秒用力呼气量(FEV1)、用力肺活量（FVC）、呼吸峰流速（PEF）、最大通气量百分比（MVV）较治疗前均有明显改善，且观察组明显高于对照组（P<0.05）；2组患者pH值差异无统计学意义（P>0.05）；观察组患者氧分压（PaO2）高于对照组、二氧化碳分压（PaCO2）低于对照组（P<0.05）；观察组患者凝血酶原时间（PT）、凝血酶时间（TT）均高于对照组，纤维蛋白原（FIB）低于对照组（P<0.05），血小板计数值（PLT）比较,差异无统计学意义（P>0.05）。所有患者住院治疗期间未有严重不良反应出现。结论：使用益气养心方联合丹参注射液治疗COPD合并肺心病疗效显著，能有效优化患者肺功能、血气指标和血凝、纤溶指标，快速缓解各项临床症状，未发生严重不良反应。 |
| English Summary: |
| To investigate clinical effects of Yiqi Yangxin Formula combined with Danshen injections in the treatment of patients with chronic obstructive pulmonary disease(COPD)and pneumocardial disease.Methods:A retrospective analysis was performed on 68 patients with COPD complicated with pneumocardial disease treated in our hospital from September 2015 to July 2016.The 68 patients were randomly divided into experimental group and control group with 34 cases in each group according to the sequence of treatment.Patients in control group were treated with intravenous injection of Mailuoning based on conventional treatment.The patients in the experimental group were treated with Yiqi Yangxin Formula combined with Danshen injections based on conventional treatment.The improvement of final curative effects and the changes of pulmonary function,blood gas index,blood coagulation and fibrinolysis of 2 groups were compared.Results:After treatment,the curative effects of experimental group were significantly higher than that of control group(P<0.05).After the course of treatment,the forced expiratory volume in 1 s(FEV1),forced vital capacity(FVC),peak expiratory flow(PEF)and maximum voluntary ventilation(MVV)were significantly improved compared with that before treatment,and the experimental group was significantly higher than that of control group(P<0.05).There was no significant difference in PH value between 2 groups(P>0.05).The partial pressure of oxygen(PaO2)in experimental group was higher than that of the control group,and the PaCO2 of experimental group was lower than that of control group(P<0.05).The prothrombin time(PT)and thrombin time(TT)in the experimental group were significantly higher than that of control group,while fibrin(FIB)indicators lower than the control group(P<0.05),and platelet count(PLT)showed no significant difference(P>0.05).No serious adverse events occurred during hospitalization in all patients.Conclusion:The treatment of COPD combined with pneumocardial disease with Yiqi Yangxin Formula and Danshen injections has significant curative effects.It can effectively optimize the pulmonary function,blood gas index,hemagglutination and fibrinolysis indexes of patients with COPD and quickly relieve the clinical symptoms without serious adverse reactions,which has the promotion and application value. |
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