To explore the clinical effect of Yiqi Huoxue Tongluo Decoction in the treatment of ischemic cerebral apoplexy. Methods:A total of 80 cases of patients with ischemic stroke in our hospital from September 2015 to June 2017 were randomly divided into observation group and control group, with 40 cases in each group. The control group was treated with conventional treatment, and the observation group was added Yiqi Huoxue Tongluo Decoction. The clinical effect of two groups of patients was compared. Results:The clinical effect of the patients was significantly higher than that in the control group, and the difference was statistically significant (P<0.05). Before treatment, CRP, IL-6 and TNF alpha index level and ADL scores of two groups had no significant difference (P>0.05). After different ways of treatment, CRP, IL-6 and TNF alpha index level value and ADL scores of observation group was better than control group. After treatment, CRP, IL-6 and TNF alpha index level value and ADL scores of two groups had statistically significant difference (P<0.05). Conclusion:Yiqi Huoxue Tongluo Decoction can effectively dredge meridian, relieve the patient's brain hypoxia, and has very good repair effect on action inconvenience caused by stroke and nerve injury. Yiqi Huoxue Tongluo Decoction can make all the drugs fully effective, nourishing qi and blood, and dredge meridian. A large number of clinical practice shows that Yiqi Huoxue Tongluo Decoction has very good therapeutic effect in patients with ischemic stroke.