| 引用本文:张孔雁，曹俊杰，王义围，王兆鹏，尹成淑，王淼.苦碟子注射液联合磷酸肌酸钠治疗老年冠心病心力衰竭患者的临床随机对照研究[J].世界中医药,2018,(11):. |
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| 苦碟子注射液联合磷酸肌酸钠治疗老年冠心病心力衰竭患者的临床随机对照研究 |
| A Randomized Controlled Trial of Kudiezi Injection Combined with Creatine Phosphate Sodium in the Treatment of Senile Patients with Coronary Heart Disease and Heart Failure |
| 投稿时间：2018-09-10 |
| DOI：10.3969/j.issn.1673-7202.2018.11.023 |
| 中文关键词: 冠心病 心力衰竭 苦碟子注射液 磷酸肌酸钠 心功能 疗效 |
| English Keywords:Coronary heart disease Heart failure Kudiezi Injection Creatine phosphate sodium Cardiac function Efficacy |
| 基金项目:承德市科学技术研究与发展计划项目(20151039) |
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| 中文摘要: |
| 目的:探究苦碟子注射液联合磷酸肌酸钠治疗老年冠心病心力衰竭及对心功能、预后的影响。方法:选取2014年8月至2016年12月承德医学院附属医院收治的老年冠心病心力衰竭患者96例,按照随机数字表法将其分为对照组和观察组,每组48例。对照组患者给予强心、扩血管及利尿等常规治疗,观察组在对照组的基础上给予苦碟子注射液联合磷酸肌酸钠治疗,2组均连续治疗2周。统计2组临床疗效及中医症候疗效;检测并比较治疗前后2组心功能指标及血清APN、NT-proBNP水平的变化。结果:与对照组比较,观察组临床疗效及中医证候疗效显效率均显著升高(P<0.05),无效率显著降低(P<0.01),且观察组临床疗效及中医证候疗效总有效率分为高达95.83%及93.75%,均显著高于对照组的66.67%及68.75%(P<0.01);与治疗前比较,治疗后观察组LVEDd及LVEDs均显著降低,LVEF显著升高,且2组间差异有统计学意义(P<0.01);与治疗前比较,治疗后观察组血清APN及NT-proBNP水平显著降低,且显著低于对照组(P<0.01)。结论:在常规治疗的基础上以苦碟子注射液联合磷酸肌酸钠治疗老年冠心病心力衰竭可明显提高治疗效果,改善患者临床症状及心功能。 |
| English Summary: |
| To explore the clinical efficacy of Kudiezi Injection combined with creatine phosphate sodium in the treatment of senile patients with coronary heart disease (CHD) and heart failure，and analyze the influence on the cardiac function and prognosis.Methods:A total of 96 senile patients with CHD and heart failure in Affiliated Hospital of Chengde Medical University from August 2014 to December 2016 were selected and divided into control group and treatment group，with 48 patients in each group.The control group was treated with the conventional therapy of cardiotonic，vascular dilation and diuresis，on the basis of which treatment group was treated with Kudiezi Injection combined with creatine phosphate sodium.The patients in the 2 groups were treated continuously for 2 weeks.The clinical efficacy and Traditioanl Chinese Medicine (TCM) syndrome efficacy of 2 groups were counted; the changes of cardiac function indexes and the levels of serum APN，NT-proBNP in 2 groups before and after treatment were detected and compared.Results:Compared with control group，the marked effective rate of clinical efficacy and TCM syndrome efficacy in treatment group increased significantly (P<0.05)，and the inefficiency rate decreased significantly (P<0.01)，and the total effective rate of clinical efficacy and TCM syndrome efficacy in treatment group were 95.83% and 93.75%，which were higher than 66.67% and 68.75% in control group (P<0.01).Compared with before treatment，the LVEDd and LVEDs of treatment group decreased significantly，which were lower than that of control group after treatment (P<0.01); and the LVEF of treatment group increased significantly，which was higher than that of control group after treatment (P<0.01).Compared with before treatment，the levels of serum APN and NT-proBNP in treatment group decreased significantly，which were lower than that in control group after treatment (P<0.01).Conclusion:Kudiezi Injection combined with creatine phosphate sodium on the basis of conventional therapy can obviously increase the therapeutic effect in senile patients with CHD and heart failure，and improve the patients' clinical symptoms and cardiac function. |
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