To observe the effects of Qiming Granules in the treatment of patients with NPDR choroid circulation and the improvement of dry eye，and to explore the mechanism of action.Methods:A total of 100 patients with non-proliferation stage of diabetic retinopathy who were hospitalized in Hebei Provincial People's Hospital were selection from April 2013 to November 2015，and they were divided into control group (using pure hydroxyl benzene sulfonic acid calcium treatment) and observation group (Qiming Granules with hydroxyl benzene sulfonic acid calcium therapy) with 50 cases in each group.After 2 months of treatment，the changes of tissue factor (TF)，pigment epithelium-derived factor (PEDG)，insulin-like growth factor-1 (IGF-1)，vascular endothelial growth factor (VEGF) and serum branched-chain amino acids of the two groups were measured and compared for analysis.Results:1）The serum TF，IGF-1，VEGF levels of the control group were significantly higher than that of observation group，but the content of PEDF was significantly lower than the observation group，with statistically significant difference (P<0.05). 2）The serum contents of valine，isoleucine，leucine of the control group were significantly higher than that of the observation group，with statistically significant difference (P<0.05). 3）The total effective rate of the treatment group was 92%，which was significantly different from that of the control group (78%)，with statistically significant difference (P<0.05).Conclusion:Qiming Granules can restrain formation of new blood vessels and improve choroid circulation，which can provide effective treatment for patients with dry eyes.