To observe the therapeutic effect and the influence of Smad7 on the levels of TGF-β1,Smad2 and protein in the treatment of asthma.Methods:Asthma patients treated in our hospital from March 2016 to March 2017 were selected as the research object,according to the treatment methods are divided into control group and observation group,the control group was given routine drug treatment,the observation group was given Xuanfei Pingchuan decoction treatment.The therapeutic effects of the two groups were observed,and the differences of lung function,inflammatory factors,TGF-beta 1,Smad 2 and Smad7 levels between the two groups before and after treatment were compared.Results:The effective rate of the observation group was 97.50%,which was higher than that of the control group (χ2=5.000,P=0.025); There was no difference in lung function between the two groups before treatment.After treatment,the lung function index of the observation group was better than that of the control group; Two groups of patients had no difference between the levels of proinflammatory cytokines,after treatment,the observation group IL-6,hs-CRP and TNF-alpha water were lower than those in control group; The levels of TGF-,beta 1,Smad2 and Smad7 in the two groups before treatment were not different.After treatment,the levels of TGF-,beta 1,Smad2 and Smad7 in the observation group were lower than those in the control group.Conclusion:The method of clearing lung and relieving asthma has better therapeutic effect on asthma.It can obviously improve the expression level of TGF-,beta 1,Smad2,Smad7 and lung function in patients with asthma,and has good clinical value.