| 引用本文:金玉，黄金龙.小柴胡汤加减对青春期痤疮的临床疗效及其对MMP-1、MMP-3、MMP-9蛋白表达的影响[J].世界中医药,2018,(11):. |
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| 小柴胡汤加减对青春期痤疮的临床疗效及其对MMP-1、MMP-3、MMP-9蛋白表达的影响 |
| Clinical Curative Effect of Xiaochaihu Decoction in the Treatment of Adolescent Acne and the Effects of MMP-1，MMP-3，MMP-9 Protein Expression |
| 投稿时间：2018-04-28 |
| DOI：10.3969/j.issn.1673-7202.2018.11.026 |
| 中文关键词: 小柴胡汤 青春期痤疮 血清炎性反应因子 内分泌功能 免疫功能 基质金属蛋白酶 临床疗效 米诺环素 |
| English Keywords:Xiaochaihu Decoction Adolescent acne Serum inflammatory factors Endocrine function Immune function Matrix metalloproteinases Clinical curative effect Minocycline |
| 基金项目:江苏省卫生计生委2015年青年科研课题(H201509) |
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| 中文摘要: |
| 目的:观察小柴胡汤加减对青春期痤疮的临床疗效及其对血清炎性反应因子、内分泌功能、免疫功能及基质金属蛋白酶水平的影响。方法:选取2016年8月至2018年3月江苏省中医院收治的青春期痤疮患者126例,按照随机数字表法随机分为对照组和观察组,每组63例。对照组给予米诺环素联合过氧化苯甲酰软膏外抹,观察组在对照组治疗的基础上给予小柴胡汤,观察2组血清炎性反应因子(IL-1、IL-6、TNF-α、IFN-γ)、激素水平(DHT、FT、SHBG)、免疫功能(IgG、IgM、IgA、补体C3、补体C4)及基质金属蛋白酶(MMP-1、MMP-3、MMP-9)变化情况。结果:观察组治疗后DHT、FT水平明显低于对照组治疗后水平(P<0.05),SHBG明显高于对照组治疗后水平(P<0.05)。与治疗前比较,2组治疗后IL-1、IL-6、TNF-α、IFN-γ、IgG、IgM、IgA、补体C3、补体C4、MMP-1、MMP-3、MMP-9水平明显降低(P<0.05);观察组上述指标变化更明显(P<0.05)。观察组的治疗有效率(92.06%)明显高于对照组(77.78%),差异有统计学意义(P<0.05)。结论:小柴胡汤具有抗炎,增强免疫力,调节内分泌功能,降低基质金属蛋白酶水平等作用,提高青春期痤疮的治疗效果。 |
| English Summary: |
| To observe the clinical curative effect of Xiaochaihu Decoction in the treatment of adolescent acne and its influence on the level of inflammatory cytokines，endocrine function，immune function and matrix metalloproteinases.Methods:A total of 126 cases with adolescent acne in Traditional Chinese Medicine Hospital of Jiangsu from August 2016 to March 2018 were selected and randomly divided into the observation group and the control group according to random number table，with 63 cases in each group.The control group was given minocycline combined with benzoyl peroxide cream，while the observational group was treated with Xiaochaihu Decoction based on the treatment of the control group.The level of serum inflammatory factors (IL-1，IL-6，TNF-α，IFN-γ)，hormone (DHT，FT，SHBG)，immune function (IgG，IgM，IgA，complement C3，complement C4) and matrix metalloproteinases (MMP-1，MMP-3，MMP-9) were observed in two groups.Results:The level of DHT and FT of the observation group were lower than that of the control group after treatment (P<0.05)，and the level of SHBG was higher than the control group after treatment (P<0.05).Compared with before treatment，the level of IL-1，IL-6，TNF-α，IFN-γ，IgG，IgM，IgA，complement C3，complement C4，MMP-1，MMP-3，MMP-9 decreased in two groups (P<0.05)，and the above index of the observation group changed more obviously (P<0.05).The total effective rate of the observation group (92.06%) was higher than that of the control group (77.78%).Conclusion:Xiaochaihu Decoction has the effects of anti-inflammatory，enhancing immunity，regulating endocrine function，reducing the level of matrix metalloproteinases，improving the therapeutic effect of adolescent acne. |
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