世界中医药

今天是

首页

期刊简介

文章摘要

引用本文:马利阁，尹万乐，尤笑迎.独一味胶囊联合塞来昔布治疗膝骨性关节炎的疗效及对血清脂质、载脂蛋白和炎性反应递质的影响[J].世界中医药,2018,(11):.

独一味胶囊联合塞来昔布治疗膝骨性关节炎的疗效及对血清脂质、载脂蛋白和炎性反应递质的影响

Clinical Observation on Duyiwei Capsule Combined with Celecoxib in the Treatment of Knee Osteoarthritis and Effect on Serum Lipid, Apolipoprotein and Inflammatory Cytokines

投稿时间：2017-10-31

DOI：10.3969/j.issn.1673-7202.2018.11.027

中文关键词: 独一味胶囊塞来昔布膝骨性关节炎疗效脂质载脂蛋白白细胞介素-1β 白细胞介素-6 肿瘤坏死因子-α

English Keywords:Duyiwei Capsule Celecoxib Knee osteoarthritis Effect Lipid Apolipoprotein Interleukin-1β Interleukins-6 Tumor necrosis factor-α

基金项目:河南省中医药科学研究专项项目（2017ZY1007）

作者	单位
马利阁，尹万乐，尤笑迎	郑州人民医院骨关节科，郑州，450000

摘要点击次数: 823

全文下载次数: 836

中文摘要:

目的：探讨独一味胶囊联合塞来昔布治疗膝骨性关节炎的疗效及对血清脂质、载脂蛋白和炎性反应递质的影响。方法：选取2016年4月至2017年4月郑州人民医院收治的膝骨性关节炎患者106例，按照随机表法分为对照组与观察组，每组53例。对照组采用塞来昔布治疗，观察组在对照组基础上结合独一味胶囊。2组疗程均为8周。比较2组治疗疗效，治疗前后视觉模拟评分法（VAS）评分、Lysholm膝关节评分、脂质、载脂蛋白及炎性反应递质水平变化。结果：2组治疗后VAS评分降低而Lysholm膝关节评分增加（观察组：t=27.9996、23.5112，对照组：t=21.4626、14.7152，P<0.05）；观察组治疗后VAS评分低于对照组而Lysholm膝关节评分高于对照组（t=23.0483、8.1119，P<0.05）。2组治疗后HDL-C和载脂蛋白a增加而TG和载脂蛋白b降低（观察组：t=13.4000、19.9701、10.7951、10.6511，对照组：t=8.7451、10.3931、6.1894、5.9974，P<0.05）；观察组治疗后HDL-C和载脂蛋白a高于对照组而TG和载脂蛋白b低于对照组（t=6.7404、11.6645、5.4722、5.4198，P<0.05）。2组治疗后IL-1β、IL-6和TNF-α水平降低（观察组：t=18.0812、19.2021、12.6070，对照组：t=8.4874、8.7542、5.9795，P<0.05）；观察组治疗后IL-1β、IL-6和TNF-α水平低于对照组（t=12.1133、11.6867、7.8065，P<0.05）。观察组治疗总有效率（92.45%）高于对照组（71.70%）（P<0.05）。结论：独一味胶囊联合塞来昔布治疗膝骨性关节炎疗效显著，可改善患者脂质、载脂蛋白及细胞炎性反应。

English Summary:

To investigate the effects of Duyiwei Capsule combined with celecoxib in the treatment of knee osteoarthritis and effect on serum lipid, apolipoprotein and inflammatory cytokines influence. Methods:A total of 106 patients with knee osteoarthritis admitted in our hospital from April 2016 to April 2017 were randomly divided into the observation group (53 cases) and the control group (53 cases). The control group was treated with celecoxib treatment, and the observation group was added Duyiwei capsule. The two groups were treated for 8 weeks. The therapeutic effects of the two groups were compared before and after treatment. VAS score, Lysholm knee score, lipid, apolipoprotein and cytokine levels were changed. Results:VAS score of two groups after treatment decreased and Lysholm knee score increased (observation group: t=27.9996, 23.5112, the control group: t=21.4626, 14.7152, P<0.05); VAS score of the observation group after treatment was lower than the control group and the Lysholm knee score was higher than the control group (t=23.0483, 8.1119, P<0.05). HDL-C and apolipoprotein A and apolipoprotein TG of two groups were increased and B decreased (observation group: t=13.4000, 19.9701, 10.7951, 10.6511, the control group: t=8.7451, 10.3931, 6.1894, 5.9974, P<0.05); HDL-C and apolipoprotein a of the observation group after treatment was higher than that of control group and TG and apolipoprotein B was lower than the control group (t=6.7404, 11.6645, 5.4722, 5.4198, P<0.05). IL-1β, IL-6 and TNF-α levels decreased in two groups after treatment (observation group: t=18.0812, 19.2021, 12.6070, the control group: t=8.4874, 8.7542, 5.9795, P<0.05); IL-1β, IL-6 and TNF-α levels after treatment in the observation group was lower than in the control group (t=12.1133, 11.6867, 7.8065, P<0.05). The total effective rate of the observation group (92.45%) was higher than that of the control group (71.70%) (P<0.05). Conclusion:The curative effect of Duyiwei Capsule combined with celecoxib in the treatment of knee osteoarthritis patients is significant, which can improve lipid, apolipoprotein and cell inflammatory reaction, with important significance.

查看全文查看/发表评论下载PDF阅读器