| 引用本文:孙赫楠1，朱曼迪2，张威1.针灸百会、涌泉穴治疗阿尔茨海默病对血浆乙酰胆碱、β-淀粉样蛋白的影响[J].世界中医药,2018,(11):. |
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| 针灸百会、涌泉穴治疗阿尔茨海默病对血浆乙酰胆碱、β-淀粉样蛋白的影响 |
| Effects of Serum Acetyl Choline and Amyloid-Beta Protein by Using Acupuncture Baihui (GV20) and Yongquan (KI1) Acupoint to Treat Patients with Alzheimer Disease |
| 投稿时间：2017-06-07 |
| DOI：10.3969/j.issn.1673-7202.2018.11.047 |
| 中文关键词: 百会穴 涌泉穴 阿尔茨海默病 乙酰胆碱 β-淀粉样蛋白 |
| English Keywords:Baihui acupoint (GV20) Yongquan acupoint (KI1) Alzheimer disease Acetyl choline Amyloid beta protein |
| 基金项目:辽宁省自然科学基金项目(201602507) |
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| 中文摘要: |
| 目的:探讨针灸百会、涌泉穴治疗阿尔茨海默病(AD)对血浆乙酰胆碱、β-淀粉样蛋白的影响。方法:选取2015年1月至2016年6月辽宁中医药大学附属医院收治AD患者110例,按照随机数表法随机分为对照组和观察组,每组55例,对照组给予安慰剂,观察组在对照组基础上给予针灸百会、涌泉穴治疗,观察2组治疗前及治疗6周(治疗后)简易精神状态评价量表(MMSE)及改良长谷川痴呆量表(HDS)评分变化,治疗前后血浆乙酰胆碱(Ach)、β-淀粉样蛋白(Aβ1-40、Aβ1-42)水平变化,并进行统计学分析。结果:治疗前,2组各项观察指标基本相同,差异无统计学意义(P>0.05)。治疗后,观察组MMSE、HDS评分均显著高于对照组,差异有统计学意义(P<0.05),观察组血浆Aβ1-40及Aβ1-42水平显著低于对照组,差异有统计学意义(P<0.05),观察组血浆Ach水平均显著高于对照组,差异有统计学意义(P<0.05)。Spearman相关性分析显示,MMSE评分与血浆Ach水平呈显著正相关(P<0.05),MMSE评分与血浆Aβ1-40及Aβ1-42水平负显著正相关(P<0.05)。HDS评分与血浆Ach水平呈显著正相关(P<0.05),HDS评分与血浆Aβ1-40及Aβ1-42水平负显著正相关(P<0.05)。结论:针灸百会、涌泉穴可有效治疗AD,通过提高血浆Ach水平,降低血浆Aβ1-40及Aβ1-42水平可能是其分子生物学机制。 |
| English Summary: |
| To discuss the effects of serum acetyl choline and amyloid-beta protein by using acupuncture Baihui (GV20) and Yongquan (KI1) acupoint to treat patients with Alzheimer disease (AD).Methods:A total of 120 patients with AD in Affiliated Hospital of Liaoning University of Traditional Chinese Medicine from January 2015 to June 2016 were selected and divided into observation group and control group with 55 cases in each group according to the random indicator method.The control group received placebo.Based on the control group，the observation group received acupuncture Baihui (GV20) and Yongquan (KI1) acupoint treatment.Changes in scores of Mini-Mental State Examination (MMSE) and Revised Hasegawa dementia scale (HDS-R)，plasma levels of acetyl choline (Ach)，and amyloid-beta protein (Aβ1-40、Aβ1-42) of two groups were observed before and after treatment.Results:Before treatment，various observation indexes of two groups was basically the same，without statistical significance (P>0.05).After treatment，scores of MMSE and HDS of observation group were significantly higher than those of control group，with statistical significance (P<0.05).The plasma levels of Aβ1-40 and Aβ1-42 of observation group were significantly higher than those of control group，with statistical significance (P<0.05).Plasma levels of Ach in observation group were significantly lower than those of control group，with statistical significance (P<0.05).As Spearman correlation analysis showed，scores of MMSE were negatively correlated with plasma levels of Aβ1-40 and Aβ1-42 (P<0.05)，and scores of MMSE were positively correlated with plasma levels of Ach (P<0.05).The scores of HDS were negatively correlated with plasma levels of Aβ1-40 and Aβ1-42 (P<0.05)，and scores of HDS were positively correlated with plasma levels of Ach (P<0.05).Conclusion:Acupuncture Baihui (GV20) and Yongquan (KI1) acupoint can be effective in the treatment of AD，whose molecular biology mechanism may be improvement of the plasma levels of Ach，decrease of the plasma levels of Aβ1-40 and Aβ1-42. |
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