| 引用本文:李长艳1，田淑霞1，2，张婧娴1，肖霄3，郭澄1，杜江2，韩永龙1，3.结合抗炎指标优化东北铁线莲挥发油提取工艺[J].世界中医药,2018,(11):. |
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| 结合抗炎指标优化东北铁线莲挥发油提取工艺 |
| Optimization of Extraction Technology of Volatile Oil from Clematis Mandshurica Combined with Anti-inflammatory Index |
| 投稿时间：2017-12-31 |
| DOI：10.3969/j.issn.1673-7202.2018.11.053 |
| 中文关键词: 东北铁线莲 挥发油 水蒸气蒸馏法 正交试验设计 提取率 一氧化氮 抑制率 |
| English Keywords:Clematis manshurica Volatile oil Steam distillation Orthogonal test Extraction rate RAW264.7 cell NO Inhibition rate Anti-inflammation |
| 基金项目:上海市科学技术委员会民生科技支撑计划专项（14401972002）；上海市第六人民医院东院院人才课题（2014010） |
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| 中文摘要: |
| 目的:结合抗炎指标优选水蒸气蒸馏法提取东北铁线莲挥发油的工艺。方法：选取东北铁线莲。以挥发油提取率、NO抑制率和两者的加权评分为指标，通过正交试验考察过筛目数、药液比和回流时间对东北铁线莲挥发油的水蒸气蒸馏法提取工艺的影响，优选最佳试验方案。结果：各因素对挥发油提取率、NO抑制率和加权评分的影响顺序为过筛目数＞药液比＞回流时间；最佳提取工艺为过筛目数3#，药液比1:10，回流时间12 h；挥发油提取率0.072%，NO抑制率117.411%，加权评分97.979。结论：水蒸气蒸馏法提取的东北铁线莲挥发油抗炎作用明显，优化的工艺稳定可靠。 |
| English Summary: |
| To optimize steam distillation extraction process of volatile oil from Clematis Manshurica combined with anti-inflammatory index.Methods:With the volatile oil extraction rate,inhibition rate of NO and weighting score as indexes,effect of mesh number,liquid ratio and reflux time on steam distillation process of volatile oil from Clematis Manshurica were investigated by orthogonal test to optimize the best test scheme.Results:Effects of three factors on volatile oil extraction rate,inhibition rate of NO and weighteing score were in order of mesh number,liquid ratio,and reflux time; Optimal extraction technology was followed:mesh number was 3#,liquid ratio was 1:10,and reflux time was 12 h; volatile oil extraction rate was 0.072%,the inhibition rate of NO was 117.411%,weighting score was 97.979.Conclusion:The volatile oil extracted from steam distillation method has significant anti-inflammatory effect and the optimized process is stable and reliable. |
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