Rehmanniae Radix,Achyranthis Bidentatae Radix,Dioscoreae Rhizoma and Chrysanthemi Flos are four types of Traditional Chinese Medicine.Because their original producing area is Huaiqingfu in ancient times,therefore were named “Four-Huaiqing Chinese medicine”.Due to the problems of declining soil quality,shrinking acreage of cultivation fields,deterioration of varieties,excessive use of chemical fertilizers,serious diseases and insect pests,agricultural residues and heavy metal issues are serious.It is significantly essential to solve these problems by carrying out the pollution-free cultivation of “Four-Huaiqing Chinese medicine”.This paper proposed a pollution-free cultivation system,including Geographic Information System (GIS) to guide land selection,combined with the “soil disinfection+green manure return+biological agents regulation” for soil preparation,modern breeding technology to develop the resistant variety breeding,seed seedling standard formulation,mainly organic fertilizer and integrated pest management.The system will provide a guidance for the production of pollution-free “Four-Huaiqing Chinese medicine” and reference for the pollution-free cultivation system of other Chinese medicinal materials.